肝癌栓塞治疗中碘化油特点的应用研究  

Clinical Research on the Characteristics of Lipiodol in Chemoembolization Therapy for Hepatic Cellular Carcinoma

作　　者：杨立[1] 夏东州[1] 张铁汉 王力非 邢冲冲[1] 

机构地区：[1]中国人民解放军总医院放射科,北京100853

出　　处：《临床放射学杂志》2000年第5期313-316,共4页Journal of Clinical Radiology

摘　　要：目的　探讨不同碘化油肝动脉栓塞后在肝脏内的分布特点。材料与方法　随机选择经影像学和细胞病理学证实的原发性肝癌患者 36例 ,分别应用普通碘油、超液化碘油及 2种碘油以 1∶1的比例混合后行肝动脉栓塞治疗。应用平片和CT复查 ,了解碘油在肝癌病变区和病灶周围正常组织内的分布。按碘油全部积聚在病灶内、多数积聚在病灶内、病灶内外均有积聚统计结果。结果　对 36例原发性肝癌分别应用普通碘油行肝动脉栓塞 (11例 )、超液化碘油栓塞 (13例 )及两者混合后栓塞治疗 (12例 ) ,经平片和CT复查发现 ,碘油完全积聚于病灶内者在普通碘油组为 91.0 % (10 /11) ,超液化碘油组为 7.7% (1/13) ,混合组为 33 .0 % (4 /12 )。超液化碘油似乎更容易于病灶内消失。结论　在肝癌应用碘油行栓塞治疗中 ,普通碘油主要积聚于病灶内 ,而超液化碘油可在病灶内。Objective To investigate the intrahepatic distribution of Lipiodol in chemoembolization therapy for primary hepatic cellular carcinoma (HCC).Materials and Methods Thirtysix patients with HCC, proved by imaging and/or biopsy, were randomly divided into three groups and were treated with common Lipiodol (n=11), Ultra Fluide Lipiodol (n=13), or a mixture of the above two preparations with a ratio of 1∶1 (n=12), respectively. The distribution of Lipiodol in the liver demonstrated on plain films and CT scans was observed in 15～20 days after chemoembolization. The distribution was graded as follows. (1) Excellent: all Lipiodol was deposited in the lesions; (2) Good: most Lipiodol was deposited in the lesions, while small amount of Lipiodol stayed in normal hepatic parenchyma; (3) Poor: Lipiodol was deposited in both lesions and normal hepatic parenchyma about equally.Results The occurrences of Lipiodol deposit seen only inside the lesions in the common group, Ultra Fluide group and mixture group were 91% (10/11), 7.7% (1/13) and 33% (4/12), respectively. Followup CT scans showed that Ultra Fluide Lipiodol easily escaped from the lesions.Conclusion In chemoembolization therapy with Lipiodol for HCC, the common Lipiodol can almost always deposit in the lesions rather than in the normal parenchyma as seen in the case of using Ultra Fluide Lipiodol.

关 键 词：原发性肝癌 碘化油 化疗栓塞 药物疗法 

分 类 号：R735.7[医药卫生—肿瘤]