AE活性酯的合成研究  

Synthesis of MAEM

作　　者：孙健[1] 

机构地区：[1]青岛农业大学化学与药学院,青岛266109

出　　处：《中国抗生素杂志》2012年第11期837-839,共3页Chinese Journal of Antibiotics

摘　　要：目的改进AE活性酯的合成工艺。方法以乙酰乙酸乙酯为起始原料,合成氨噻肟酸,再与DM反应得到AE活性酯,AE活性酯的结构采用核磁共振氢谱确证。结果得到的AE活性酯总收率达39.4%,高于现有文献值。结论该合成方法简单,易于产业化。Objective To improve the synthesis process of MAEM. Methods Taking acetoacetate as start material, 2-（2-Aminothiazole-4-yl）-2-methoxyiminoacetie acid was synthesized, after the reaction with DM and with the optimized route and techniques, a perfect way of synthesizing MAEM has been sought out. The structure of MAEM was confirmed by ~H-NMR. Results The target compound was obtained with total yield of 39.4%, which is higher than that in any other current report. Conclusion This method was simple, and easy to be industrialization.

关 键 词：AE活性酯 氨噻肟酸 合成 

分 类 号：O623.624[理学—有机化学]