兔膝关节软骨下自体骨移植后不同固定时间对软骨的影响  

Effect of different time of fixation on cartilage after subchondral replacement with autogenous bone in rabbits

作　　者：李建军[1] 金成壁[1] 黄东辉[2] 

机构地区：[1]中国医科大学附属第一医院,辽宁沈阳110001 [2]鞍钢铁东医院骨科

出　　处：《中国冶金工业医学杂志》2000年第2期72-73,共2页Chinese Medical Journal of Metallurgical industry

摘　　要：目的 :研究兔膝关节软骨下自体骨移植后不同固定时间对关节软骨的影响。方法 :健康大耳白兔 54只按术后膝关节不同固定时间随机分为A、B、C 3组。建立膝关节软骨下自体骨移植的动物模型 ,于术后 8周取材 ,采用光镜、透射电镜对关节软骨进行形态学观察。结果 :A组 2 4 %的关节软骨出现退变 ;B组 1 3 %的关节软骨出现退变 ;C组 2 0 3 %关节软骨出现退变。B组与A组、C组相比 ,有显著性差异。结论 :术后合理负重可降低关节软骨退变的发生率。Objective:To explore the influence of different time of fixation on cartilage after subchondral replacement with autogenous bone in rabbits.Methods:Fifty-four rabbits were divided into three groups according to different time of fixation.The cartilage changes were observed in eight weeks after operation.Results:Twenty-four percent articular cartilage degenerated in group A,13% cartilage degenerated in group B,20 3% degenerated in group C.Conclusions:Proper load can reduce the risk of postoperative cartilage degenerating.

关 键 词：关节软骨 骨缺损 自体骨转移 

分 类 号：R738.1[医药卫生—肿瘤]