脑出血患者血肿周围星形细胞内皮素-1表达免疫组化研究  

A study of endothelin-1 expression in reactive astrocytes surrounding the hematoma in cerebral hemorrhage

作　　者：黄勇华[1] 张微微[1] 郝小淑[1] 周进和 史晓东[3] MargarettaBjoeling 

机构地区：[1]北京军区总医院神经内科,北京100700 [2]北京军区军事监狱卫生所,北京108050 [3]北京军区总医院骨科实验室,北京100700 [4]瑞典Uppsala大学病理研究所

出　　处：《军医进修学院学报》2000年第1期5-7,共3页Academic Journal of Pla Postgraduate Medical School

基　　金：国家自然科学基金!资助项目 ( 3 9770 75 3 )

摘　　要：目的 :探讨内皮素 - 1与星形细胞之间相互关系及其在脑出血的作用。方法 :采用内皮素 - 1抗体 SP免疫组化技术对脑出血患者尸检材料血肿周围脑组织反应性星形细胞内皮素 - 1表达水平进行检测。结果 :发现脑出血组反应性星形细胞增生、肥大变性 ,存在内皮素 - 1的表达 ,而对照组星形细胞形态基本正常 ,偶见阳性。结论 :内皮素 -Objective:To investigate the expression of endothelin 1 in astrocytes in the human brain with cerebral hemorrhage.Methods:The SP immunohistochemical method and a polyclonal antiserum were used. Autopsy material was obtained from 8 cases of cerebral hemorrhage, 5 cases without brain diseases. Results:Endothelin 1 was expressed in numerous reactive astrocytes in the human brain surrounding the hematoma. But this occurred in only exceptional astrocytes of controls. Conclusion:The results suggest that endothelin 1 might play an essential role in the pathogenesis of edema formation and ischemia injury after cerebral hemorrhage.

关 键 词：脑出血 星形细胞 内皮素-1 免疫组织化学 

分 类 号：R743.340.2[医药卫生—神经病学与精神病学]