中国三地区真菌性角膜病致病菌种的调查  

Spectrum of mycotic keratitis in China

作　　者：王丽娅[1] 张月琴[1] 王印其[1] 王刚生[2] 卢嘉彪[3] 邓洁华 

机构地区：[1]河南省眼科研究所,郑州450003 [2]河北医科大学附属第二医院 [3]中山医科大学中山眼科中心

出　　处：《中华眼科杂志》2000年第2期138-140,共3页Chinese Journal of Ophthalmology

基　　金：河南省科委科技攻关基金资助项目!(971200253)

摘　　要：目的　调查中国华中、华北及华南三地区真菌性角膜病致病菌的情况。方法　对我国华中地区郑州市、华北地区石家庄市以及华南地区广州市 1975年 1月至 1997年 6月间 6 15例真菌性角膜炎患者的致病菌进行调查分析。结果　 6 15例真菌性角膜炎患者病灶标本的菌种共分 18属 47种。华北及华中地区的主要致病菌属基本相同 ,依次为镰孢菌属、曲霉属及青霉属 ,但主要致病菌种两地区略有差异 ;而华南地区 1975年 1月至 1986年 12月调查显示 ,主要致病菌依次为曲霉属、镰孢霉属及青霉属 ,1989～ 1997年则依次为镰孢菌属、曲霉属、弯孢霉属。Objective To investigate the spectrum of mycotic keratitis in China Methods We scraped and evaluated 615 mycotic keratitis in microbiology laboratories of Zhengzhou (central China), Shijiazhuang (north China) and Guangzhou (south China) in the twentytwo years between Jan 1, 1975 and Jun 30, 1997 Results Organisms of 18 genuses and 615 species isolated from corneal ulcers were found Fusarium species were isolated the most frequently (650% in Zhengzhou, 333% in Shijiazhuang and 392% in Guangzhou), followed by Aspergillus (205% in Zhengzhou, 217% in Shijiazhuang, 307% in Guangzhou), Penicillium (36% in Zhengzhou, 116% in Shijiazhuang) and Curvularis (131% in Guangzhou) Between Jan1, 1975 and Dec 31, 1986, Aspergillus species were most commonly isolated in Guangzhou (485%), followed by Fusarium (277%) and Penicillium (1427%) Conclusions Just as different regions of the world are characterized by specific endemic infections, the predominating organisms in corneal fungal infections also vary throughout the world These regional differences in causative organisms in mycotic keratitis are clinically important because they influence the initial and more definite therapy This study shows that Fusarium species are the most common organisms of mycotic keratitis in China

关 键 词：真菌性角膜病 致病菌种 调查 

分 类 号：R772.2[医药卫生—眼科] R379[医药卫生—临床医学]