阿卡波糖在合并糖代谢异常的心血管疾病患者中的早期应用效果观察  

Effect of Early Application of Acarbose in Cardiovascular Patients Complicated with Abnormal Glucose Metabolism

作　　者：石泉[1,2] 孙志刚[1,2] 黄欢[1,2] 黄艳[1,2] 李金程[1,2] 李国彪[1,2] 

机构地区：[1]江西省抚州市第一人民医院 [2]南昌大学第五附属医院心内科,江西抚州344000

出　　处：《临床医学工程》2012年第11期1969-1970,1972,共3页Clinical Medicine & Engineering

摘　　要：目的探讨心内科疾病的血糖如何检测,以及阿卡波糖在合并糖代谢异常的心血管疾病患者中的早期应用效果。方法收集近1年来本院心内科收住院的心血管疾病患者100例,住院期间行OGTT试验及糖化血红蛋白(HbA1c)检测(其中急性心肌梗死患者于急性期过后检测),对所有糖代谢异常患者行阿卡波糖干预,3月后复查空腹血糖(FBG)和糖化血红蛋白(HbA1c),前后比较有无差异性。结果 OGTT共发现61例糖代谢异常患者,高血压组糖代谢异常为20例(50%),稳定性心绞痛为19例(63.3%),急性心肌梗死为22例(73.3%),而FBG检测只发现25例,各组合并糖代谢异常的患者,服用阿卡波糖后的FBG和HbA1c均有降低(P<0.05)。结论对住院的高血压、冠心病患者,单纯行FBG监测会造成大量糖代谢异常患者漏诊,而常规OGTT试验有助于早期筛查和及时干预,阿卡波糖不仅有效控制餐后血糖,对控制HbA1c和FBG也有积极作用。Objective To investigate the detecting methods of blood glouse in patients with cardiovascular disease, and effects of early application of acarbose in patients complicated with abnormal glucose metabolism. Methods A total of 100 inpatients with cardiovascular disease were selected from the deparUnent of cardiology in the recent one year. Oral glucose tolerance test （OGTT） and glycosylated hemoglobin （HbAlc） were detected during the hospitalization stay, and the patients with acute myocardial infarction were detected following the acute stage, the patients with abnormal glucose metabolism added in application of acarbose for 3 months. Reexamination by fasting blood glucose （FBG） and Glycosylated Hemoglobin （HbA lc） was taken 3 months later. Results Total of 61 cases complicated with abnormal glucose metabolism found by OGTT, were divided into hypertension group, n = 20 （50%）, stable angina group, n = 19 （63.3%）, and acute myocardial infarction group, n = 22 （73.3%）, only 25 cases were found by FBG, the FBG and HbAlc of these cases decreased in different degrees by acarbose intervention （P 〈0.05）. Conclusions Large number of patients complicated with abnormal glucose metabolism will be misdiagnosed only by FBG, conventional oral glucose tolerance test will be helpful to early screening and timely intervention. Acarbose can not only control postprandial blood glucose effectively, but also play a positive role in FBG and HbAlc.

关 键 词：心内科 糖代谢异常 口服葡萄糖耐量试验 阿卡波糖 

分 类 号：R151.41[医药卫生—营养与食品卫生学] R541[医药卫生—公共卫生与预防医学]