卵母细胞成熟调控的分子机制及进展  

Progress in the Molecular Mechanisms of Oocyte Maturation

作　　者：张哲[1] 卢光琇[1] 

机构地区：[1]中南大学湘雅医学院生殖与干细胞工程研究所&中信湘雅生殖与遗传专科医院,湖南长沙410078

出　　处：《现代生物医学进展》2012年第30期5991-5993,共3页Progress in Modern Biomedicine

摘　　要：卵母细胞的成熟是人类配子发育成熟,进而形成胚胎的必然阶段。目前已知有多种因素调控卵母细胞的成熟。成熟促进因子(MPF)是卵母细胞成熟调控的最重要分子,它通过CDK1亚基的磷酸化及cyclin B累积合成调节卵母细胞的成熟。MAPK/Mos及cAMP均可通过影响MPF的活性从而间接调控卵母细胞成熟。这三者之间又存在相互影响相互作用,形成一个复杂的调控网络。阐明卵母细胞成熟的分子机制有利于为治疗女性不孕症及卵母细胞体外培养成熟提供可靠的理论依据。The maturation of oocyte is the necessary stage of human gamete development to embryo. It＇s well known that the oocyte maturation is regulated by various factors. M-phase promoting factor （MPF） is the most important regulator of oocyte maturation. Cyclin dependent kinase 1 （CDK1） and cyclin B are the two subunits of MPF. MFP regulates oocyte maturation though CDKI phosphorylation and cyclin B synthesis. Mitogen-activated protein kinase（MAPK）/Mos and cyclic adenosine monophosphate（cAMP） are another key factors that control oocyte maturation by influencing MPF activity. The MPF, MAPK/Mos and cAMP influence and interact each other, compositing a complicated regulatory networks. To elucidate the exact molecular mechanism of oocyte maturation is favorable for treating female infertility and provides the theory basis for in vitro maturation of oocyte.

关 键 词：卵母细胞 成熟促进因子 有丝分裂原激活的蛋白激酶 原癌基因产物Mos 环磷酸腺苷 

分 类 号：Q344[生物学—遗传学] R394.1[医药卫生—医学遗传学]