慢性肝病肝纤维化指标的临床研究  

A Study of Relationship between the Serum Levels of Indexes on Liver Fibrosis and Chronic Liver Disease

作　　者：倪宏[1] 马佩球[1] 朱科伦[1] 艾玲保[2] 赖建红[1] 叶新民[1] 

机构地区：[1]广州医学院第一附属医院肝病研究室,广州510120 [2]中山医科大学卫生学院,广州510080

出　　处：《现代临床医学生物工程学杂志》2000年第1期24-25,共2页Journal of Modern Clinical Medical Bioengineering

摘　　要：目的探讨肝纤维化指标包括透明质酸（ＨＡ）、Ⅲ型前胶原（ＰＣⅢ）、层粘蛋白（ＬＮ）及 Ⅳ型胶原（Ⅳ－Ｃ）等与慢性肝病的关系方法应用放免法检测１０３例慢性乙型肝炎患者、４２例肝细胞癌和６４例肝炎肝硬变患者及４０例正常人的ＨＡ、ＰＣⅢ、ＬＮ和Ⅳ－Ｃ的值．结果慢性乙型肝炎轻、中、重度病人这四项血清学指标依次升高；慢性肝炎（重度）、肝硬化、肝细胞癌的四项指标均有明星升高．结论慢性乙型肝炎（重度）、肝炎肝硬变和肝细胞癌患者与肝纤维化有密切关系；上述四项指标的联合应用有助于慢性肝病肝纤维化的诊断．Aim To investigate the relationship between the serum levels of hyaluronic acid (HA), procollagen type Ⅲ (PCⅢ), laminin(LN) , type Ⅳ collagen (Ⅳ-C) as marks of liver fibrosis and chronic liver diseases. Methods The levels of serum HA, PCⅢ, LN and Ⅳ-C were measured by means of radioimmunoassay (RIA) in 103 patients with chronic viral hepatitis B,42 patients with hepatocelllular carcinoma, 64 patients with hepatocirrhosis and 4o healthy subjects. Results The levels of serum HA, PCⅢ, LN and Ⅳ-C in groups of chronic hepatitis (severe degree), hepatocirrhosis, hepatocellular carcinoma were higher than those of groups of chronic hepatitis (mild and middle degree) and healthy subjects. Conclusions Hepatofibrosis is close related to chronic hepatitis (severe degree), hepatocirrhosis, hepatocellular carcinoma; The diagnosis of hepatofibrosis is easy to establish by the measure of four serum components (HA, PCⅢ, LN, Ⅳ-C).

关 键 词：肝纤维化 慢性肝病 透明质酸 PCⅢ 层粘蛋白 

分 类 号：R575.2[医药卫生—消化系统]