盐藻β-胡萝卜素对恶性肿瘤病人红细胞免疫粘附肿瘤细胞能力的影响  

EFFECTS OF β-CAROTENE FROM DANALIELLA SALINA ON ERYTHROCYTES ADHESION TO CELLS IN PATIENTS WITH MALIGNANT TUMOR

作　　者：刘成玉[1] 王春波[1] 蓝孝贞[1] 段建华[1] 仲维珍 谭润鸾[1] 

机构地区：[1]青岛大学医学院,青岛266021

出　　处：《中国海洋药物》2000年第1期30-32,共3页Chinese Journal of Marine Drugs

基　　金：国家科委"八五"科技攻关项目!(编号 85- 0 8- 0 7)

摘　　要：目的 :探讨盐藻β-胡萝卜素 (β- carotene,β- c)红细胞免疫粘附肿瘤细胞能力的影响。方法 :采用红细胞C3b受体花环试验和肿瘤细胞花环试验 ,检测了 36例正常人和 42例肿瘤病人红细胞 C3b受体花环率 (E-C3b RRR)和肿瘤红细胞花环率 (TERR) ,及不同浓度 β- c对 E- C3b RRR和 TERR的影响。结果 :肿瘤病人 E-C3b RRR和 TERR明显低于正常人 (P<0 .0 0 1 ) ,红细胞与不同浓度β- c温育后 ,正常人和肿瘤病人EC3b RRR和 TERR较温育前明显增高 ,差异有显著性 (P<0 .0 1 ,0 .0 0 1 ) ,当 β- c浓度为 5.0 0 %时 ,E-C3b RRR和 TERR最高。但肿瘤病人 E- C3RRR和 TERR仍低于正常人 (P<0 .0 0 1 )。结论 :β- c的抗肿瘤作用可能与其激活红细胞To explore the effects of β carotene from Dunaliella Salina on eryhtrocyte's adhesion to turnor cells.By means of the erythrocyte C3b receptor rosette test and the tumor erythrocyte rosette test,the erythrocyte C3b receptor rosette rete(E-C3bRR)and tumor erythrocyte rosette rate(TERR)were measured in 36 controls and 42 malignant tumor patients.These results indicate that E-C3bRRR and TERR were significangly lower in malignant tumor patiemts than those in controls(P<0.001).After eryhtrocyte in cubated with different concentration of β carotene,the E C3bRRR and TERR were significantly higher than before incubated in controls and malignent tumor patients(P<0.01,0.001),and the E-C3bRRR and TERR were highest when the concentrtion of β carotene was 5.00%,but the E-C3bRRR and TERR were still lowerin malignant tumor patients than controls (P<0.001).The anti-tumor action of β carotene was related to activating the erythrocyte immune function.

关 键 词：盐藻胡萝卜素 红细胞 免疫粘附 恶性肿瘤 

分 类 号：R730.53[医药卫生—肿瘤] R931.77[医药卫生—临床医学]