基于弹性网络模型的细胞色素c折叠核的识别研究  

Identification of folding cores for cytochrome c based on elastic network model

作　　者：苏计国[1] 郝锐[1] 

机构地区：[1]燕山大学理学院,河北秦皇岛066004

出　　处：《燕山大学学报》2012年第5期465-470,共6页Journal of Yanshan University

基　　金：国家自然科学基金资助项目(10947014)

摘　　要：来自细菌的细胞色素c与来自马的细胞色素c具有很高的序列和结构相似性,但是二者的折叠/去折叠路径及折叠核的位置具有很大的差异,导致这种差异的原因目前并不清楚。本文采用迭代的高斯网络方法研究了上述两个蛋白的去折叠过程,并成功识别出两个体系的折叠核位置,与实验很好地吻合。结果表明,两个体系拓扑结构的差异是导致二者折叠特征和折叠核位置不同的主要原因。Pseudomonas aeruginosa ferricytochrome c551 and horse cytochrome c have high sequential and structural homology, however,their folding/unfolding pathway and folding core are largely different.The reasonwhy they have different folding behaviors is not clear.In the present work,the unfolding processes of these two proteins are studied by using the iterative Gaussian network method.Then the folding cores of these two protein are identified,which is well consitent with the experimental result.All the results imply that the differences in the folding properties and folding core postiton between these two proteins attribute to their different structural topology.

关 键 词：细胞色素C 折叠核 弹性网络模型 拓扑结构 

分 类 号：Q617[生物学—生物物理学]