上海市陆家嘴地区公司职员非酒精性脂肪肝发病率及危险因素分析  

Prevalence of non-alcoholic fatty liver disease in office workers of Shanghai Lujiazui District and its risk factors

作　　者：赵红梅[1] 张洁[1] 杨小青[1] 周洁如[1] 韩捷[1] 

机构地区：[1]同济大学附属东方医院特诊部,上海200120

出　　处：《同济大学学报（医学版）》2012年第5期110-114,共5页Journal of Tongji University(Medical Science)

摘　　要：目的明确上海市陆家嘴地区公司职员非酒精性脂肪肝(non-alcoholic fatty liver disease,NAFLD)的发病率及相关危险因素。方法选取从2008年1月到2011年8月来同济大学附属东方医院体检的上海市陆家嘴地区公司在职职员,进行血液及肝脏超声检查。结果共3 532人完成调查,其中男性1 709人,平均年龄(41.99±9.04)岁,共检出NAFLD患者1 265例,患病率为35.8%,其中男性患病率为53.5%,女性为19.1%,男女性患病率均在41～50岁年龄组达到高峰(分别为61.3%和27.4%),在各个年龄组中男性患病率均高于女性(P<0.01)。Logistic回归分析发现年龄、体质量、血尿酸、血HDL-C及ALT与NAFLD独立相关。结论陆家嘴地区公司在职职员中NAFLD发病率高,与年龄、体质量、血尿酸、HDL-C及ALT水平相关。Objective To determine the prevalence and risk factors of non-alcoholic fatty liver disease （NAFLD） among office workers of Shanghai Lujiazui District. Methods Total 3 532 office workers with a mean age of 41. 9 y, including 1709 men and 1823 women from Lujiazui District underwent health check-up in our hospital from August 2008 to August 2011. The results of physical examination, blood tests and sonography examination were analyzed. Results NAFLD was found in 1 265（35.8% ） subjects, with a prevalence rate of 53.5% in males and 19. 1% in females. The prevalence of NAFLD in 41-50 age group was highest in both sex （61.3% and 27.4% for male and female respectively）. Multivariate logistic regression analysis showed that age, body weight, blood uric acid, HDL-C and ALT levels were closely related to NAFLD. Conclusion NAFLD is a common finding in office workers of Shanghai Lujiazui District; age, weight, uric acid, HDL-C and ALT are risk factors for NAFLD.

关 键 词：非酒精性脂肪肝 患病率 危险因素 

分 类 号：R575.5[医药卫生—消化系统]