单光子发射计算机断层扫描早期诊断阿尔茨海默病的研究  

Study on early diagnosis of Alzheimer′s disease using single photonemissioncom putedtomography

作　　者：尹刚[1] 任伯绪[2] 

机构地区：[1]长江大学荆州临床医学院荆州市中心医院,434020 [2]长江大学医学院

出　　处：《实用医技杂志》2012年第11期1125-1127,共3页Journal of Practical Medical Techniques

基　　金：湖北省卫生厅科研项目(JX5B66)

摘　　要：目的利用单光子发射计算机断层扫描(SPECT)探讨阿耳茨海默病(AD)的早期诊断,以及与AD患者神经心理学改变的关系。方法 50例可疑AD患者和50名健康对照组行CT,磁共振成像(MRI),SPECT以及临床神经心理量表检查,定量分析求出各脑叶计数与同侧小脑单位面积内平均放射性计数的比值,即脑血流指数和认知障碍之间进行相关性分析。结果 AD患者双侧脑血流指数呈不对称性降低,并与AD早期认知障碍不对称性吻合,以及神经心理不对称指数之间具有密切相关关系。结论 AD患者早期阶段已发生了血流速度的减低,SPECT是早期诊断AD的有效手段。Objective To explore the usefulness of single photonemissioncom putedtomography （SPECT） for early diagnosis of Alzheimer＇s disease （AD）, and the relationship between AD and cerebral blood supply. Methods Fifty mild AD patients and fifty healthy controls were subjected by CT, MRI, Mini-Mental State Examination （MMSE）, and SPECT examinations. Correlation analysis was undertaken between these results. Results AD patients showed abilaterally asymmetric reduction of regional radioactivity of flow （RARflow）, These changes in RARflow were coincided with AD congnitive impairment. There was a positive significant correlation between frontotemporal cognitive asymmetry indexes. Conclusion AD patients in early stage have a reduction of RARflow, SPECT is a powerful tool for AD early diagnosis.

关 键 词：体层摄影术 计算机 单光子 阿尔茨海默病 痴呆 

分 类 号：R749.1[医药卫生—神经病学与精神病学]