透明质酸钠/魔芋葡甘聚糖多孔支架的仿生矿化研究  

Bio-mineralization Investigation of SH/KGM Porous Scaffold

作　　者：王静[1] 陈佳[1] 崔永顺[1] 黄明华[1] 陈庆华[1] 

机构地区：[1]昆明理工大学材料科学与工程学院,昆明650093

出　　处：《材料导报》2012年第22期20-22,共3页Materials Reports

基　　金：云南省应用基础研究重点项目(2009CC020);昆明理工大学科学研究基金(200927006)

摘　　要：以魔芋葡甘聚糖(KGM)、透明质酸钠(SH)为主要原料,氨水为交联剂,制备SH/KGM多孔支架材料。将支架用钙盐溶液进行预钙化处理后,在模拟体液(Simulated body fluid,SBF)中浸泡仿生。仿生矿化后,对支架进行XRD、EDS、SEM分析。结果表明,仿生矿化后的SH/KGM多孔支架材料表面有圆球状羟基磷灰石颗粒沉积,且结晶度低、颗粒小;支架抗压强度及体外降解率均有相应的提高,是一种具有发展潜力的新型骨修复材料。Porous scaffolds were prepared with sodium hyaluronate （SH） and Konjac glucomannan （KGM） via gellation method. Ammonia was used as crosslinker in the gellation process. The SH/KGM composites were pretrea- ted with calcium containing sollution and then biomimetic mineralized in simulated body fluid （SBF）. The bio-mine- ralized composites were characterized by XRD, EDS and SEM analysis. The results showed that hydroxyapatite crys- tals were already formed on the surface of the SH/KGM, and the hydroxyapatite particles were spherical with tow crystallinity and small diameters. Meanwhile, it was observed that the mechanical strength and degradation rate in- creased after the scaffolds were bio-mineralized. Therefore, the bio-mineralized SH/KGM porous scaffolds are a novel kind of bone substitution materials with great potentials.

关 键 词：透明质酸钠 魔芋葡甘聚糖 羟基磷灰石 仿生矿化 

分 类 号：R318.08[医药卫生—生物医学工程]