老年高血压和2型糖尿病患者AGT基因多态性和颈动脉超声变化的关系  

The relationship between AGT gene polymorphism and carotid ultrasound changes in elderly patients with hypertension and type-2 diabetes mellitus

作　　者：浦剑虹[1] 刘健[2] 李建中[1] 吴秀英[1] 钱惠英[1] 

机构地区：[1]苏州大学附属第一医院老年科,江苏苏州215006 [2]苏州大学附属第一医院口腔科,江苏苏州215006

出　　处：《苏州大学学报（医学版）》2012年第5期681-683,725,共4页Suzhou University Journal of Medical Science

摘　　要：目的观察老年高血压及合并2型糖尿病(T2DM)患者血管紧张素原(AGT)基因多态性与颈动脉超声变化的关系。方法选择203例住院的老年人分成高血压组(105例)、高血压合并T2DM组(38例)和对照组(健康老年体检者60人)3组。入院后测血脂,行颈动脉超声检查,采用聚合酶链反应(PCR)及限制性片段长度多态性分析法进行M235T多态性检测。结果 (1)AGT基因的TT基因型及高血压合并T2DM组的颈动脉超声异常率增高,以多支病变为主;(2)颈动脉超声有多支病变的,其血脂水平明显升高(P<0.05)。结论老年高血压和T2DM患者颈动脉超声异常发生率明显增加,而血脂水平的升高及AGT基因的TT基因型使动脉粥样硬化进一步加强。Objective To observe the relation between angiotensinogen（AGT） gene polymorphism and carotid ultrasound change in the elderly hypertensive patients with type 2 diabetes mellitus（T2DM）.Methods Two hundred and three cases of hospitalization of the elderly were divided into three groups,105 cases of elderly patients with hypertension;38 cases of elderly hypertensive patients with T2DM;60 cases of healthy elderly subjects（the control group） and lipids were measured after admission and carotid ultrasonography were performed.The M235T polymorphism detection was carried out by polymerase chain reaction（PCR） and restriction fragment length polymorphism analysis.Results（1） TT genotype of AGT gene and elderly hypertensive with T2DM group carotid ultrasound abnormal rate increased and multi vessel disease was the main occurrence.（2） Multiple vessel disease of the carotid artery ultrasound and their blood lipid level were significantly increased.Conclusion Hypertension and T2DM in elderly patients,carotid artery ultrasound abnormalities are significantly increased,while the elevated lipid levels and the TT genotype of the AGT gene artery atherosclerosis is further enhanced.

关 键 词：血管紧张素原基因多态性 等位基因频率 高血压 2型糖尿病 动脉硬化 超声检查 

分 类 号：R544.11[医药卫生—心血管疾病] R587.1[医药卫生—内科学]