Caveolin-1、P63及CK34βE12蛋白在前列腺癌中的表达及临床意义  

Expression of Caveolin-1,P63 and CK34βE12 in prostate cancer and its clinical significance

作　　者：卢桂尧[1] 曾永威[1] 高婉仪[2] 禤丽萍[2] 邓学斌[1] 付汐[3] 范小明[3] 杨永强[4] 

机构地区：[1]广东医学院附属三水医院泌尿外科,广东佛山528100 [2]广东医学院附属三水医院超声科,广东佛山528100 [3]广东医学院附属三水医院病理科,广东佛山528100 [4]广东医学院附属三水医院检验科,广东佛山528100

出　　处：《苏州大学学报（医学版）》2012年第5期704-709,共6页Suzhou University Journal of Medical Science

基　　金：佛山市科技攻关项目(201008228)

摘　　要：目的探讨Caveolin-1、P63及CK34βE12蛋白在前列腺癌(Pca)中的表达及其临床意义。方法应用免疫组织化学(SP)法检测59例Pca、15例高级别前列腺上皮内瘤变(HGPIN)、11例低级别前列腺上皮内瘤变(LG-PIN)、7例非典型性腺瘤样增生(AAH)、10例基底细胞增生(BCH)、69例前列腺良性增生(BPH)标本中的Caveolin-1和P63及CK34βE12蛋白的表达情况。结果 Pca、HGPIN、LGPIN、AAH、BCH、BPH中Caveolin-1阳性表达率依次为69.49%、40.00%、45.45%、28.57%、30.00%、8.70%,P63阳性表达率依次为8.47%、86.67%、90.91%、85.71%、90.00%、97.10%,CK34βE12阳性表达率依次为8.47%、93.33%、90.91%、100%、90.00%、95.65%。Caveolin-1、P63、CK34βE12抗原在Pca与其他病变之间的表达差异均有统计学意义(均P<0.05)。Caveolin-1表达强弱与Pca的Gleason评分、临床分期相关(均P<0.05)。结论 Caveolin-1与Pca的发生、发展、侵袭、转移有关,联合检测Caveolin-1、P63及CK34βE12的表达将对Pca的早期诊断准确性、判断病情以及预后有一定临床指导意义。Objective To investigate the expression of Caveolin-1,P63 and CK34βE12 protein expression in prostate lesions and its clinical significance.Methods Immunohistochemical staining of Caveolin-1,P63 and CK34βE12 in 59 cases of prostate cancer were performed by using En Vision among with 15 cases were high grade prostatic intraepithelial neoplasia（HGPIN）,11 were low grade prostatic intraepithelial neoplasia（LGPIN）,7 were atypical adenomatous hyperplasia（AAH）,10 were basal cell hyperplasia（BCH） and 69 were benign prostate hyperplasia（BPH）.Results The positivity expression rate of Caveolin-1 in prostate cancer,HGPIN,LGPIN,AAH,BCH and BPH was 69.49%,40.00%,45.45%,28.57,30.00,8.70% respectively,the positivity expression rate of P63 was 8.47%,86.67%,90.91%,85.71%,90.00%,97.10% respectively,the positivity expression rate of CK34βE12 was 8.47%,93.33%,90.91%,100%,90.00%,95.65% respectively.The expression of Caveolin-1,P63,CK34βE12 antigen in prostate cancer and BPH specimens was significantly different（P0.05）.The expression and its strength of Caveolin-1 was related to the prostate cancer Gleason score and clinical stage（P0.05）.Conclusion The expression of Caveolin-1 may relate to the malignant development,invasion and metastasis in prostate cancer.Combined detection of the expression of Caveolin-1,P63,and CK34βE12 can be helpful for the early accurate diagnoses of prostate cancer and the malignancy and prognosis of prostate cancer.

关 键 词：前列腺肿瘤 CAVEOLIN-1 P63 CK34ΒE12 免疫组织化学 

分 类 号：R737.25[医药卫生—肿瘤]