盐酸氨溴索对缺氧缺血性脑病新生儿血浆8-异前列腺素F2α水平的影响  

Determinating of plasma 8-iso-PGF2αlevels and therapeutic effect of ambroxol in the neonates with hypoxic-ischemic encephalopathy

作　　者：李焕琼 李思涛[2] 肖昕[2] 陈文清[3] 

机构地区：[1]广东省佛山市三水人民医院儿科,广东佛山528100 [2]中山大学附属第六医院新生儿科,广东广州510655 [3]广东省湛江市妇幼保健院,广东湛江524000

出　　处：《中国当代医药》2012年第24期16-17,21,共3页China Modern Medicine

基　　金：广东省医学科学技术研究基金资助项目(A2004717)

摘　　要：目的测定缺氧缺血性脑病(HIE)新生儿血浆8-异前列腺素F2α(8-iso-PGF2α)水平及其盐酸氨溴索应用前后变化,探讨HIE的脂质过氧化损伤机制及盐酸氨溴索的抗氧化效果。方法 HIE(中度)足月儿51例,随机分为常规治疗组(26例)和氨溴索治疗组(25例)。另选正常足月儿25例作为正常对照组。常规组采用一般常规治疗方案;氨溴索组在常规治疗基础上加用氨溴索30mg/(kg.d)。治疗于生后第1天开始,3d为1个疗程。于治疗前后(生后第1、3、7天)收集外周血,酶联免疫法检测血浆8-iso-PGF2α浓度。结果 (1)治疗前,常规治疗组和氨溴索治疗组患儿血浆8-iso-PGF2α水平均明显高于正常新生儿水平,差异有高度统计学意义(P<0.01)。(2)治疗后第7天,常规治疗组患儿血浆8-iso-PGF2α水平仍高于同期正常新生儿水平,差异具有高度统计学意义(P<0.01);氨溴索治疗组患儿血浆8-iso-PGF2α水平下降,接近于同期正常新生儿水平。结论 HIE患儿存在脂质过氧化作用,盐酸氨溴索具有抗氧化作用,可使HIE患儿体内8-iso-PG2α水平下降,有必要加用。Objective To determinate plasma 8-iso-prostaglandin F2α（8-iso-PGF2α）levels,and to investigate the clinical effect of ambroxol on lowering 8-iso-PGF2αconcentration in the neonates with hypoxic-ischemic encephalopathy（HIE）.Methods Fifty one moderate HIE full-term neonates were recruited as group routine therapy（26 cases）and group ambroxol therapy[25 cases,30 mg/（kg.d）].Therapeutic intervention started 1 day after birth,3 days for one period of treatment.In addition,25 full-term neonates without HIE were serve as control.Plasma samples from HIE and normal neonates were collected on day 1 and 3 after birth.Plasma 8-iso-PGF2αlevels were determined by EIA assay.Results（1）Before intervention,plasma 8-iso-PGF2αlevels in group ambroxol and group routine were obviously higher than level of normal newborn infants.The differences were statistically significant（P0.01）.（2）7 days after treatment,group routine were obviously higher than normal level of newborn infants,the differences were statistically significant（P0.01）,and plasma 8-iso-PGF2αlevel closed to normal level of newborn babies in group ambroxol.Conclusion Lipid peroxidation exists,and high-dose ambroxol as antioxidant can markedly decrease 8-iso-PG2αlevel in HIE neonates.It is necessary for ambroxol in HIE therapeutic regime.

关 键 词：缺氧缺血性脑病 8-异前列腺素F2Α 新生儿 盐酸氨溴索 

分 类 号：R722.12[医药卫生—儿科]