肺癌患者血浆纤维蛋白原和D-二聚体检测及意义  

Research on association of the level of plasma fibrinogen and D-dimer with lung cancer

作　　者：吴文奇[1] 梁燕明[1] 

机构地区：[1]肇庆医学高等专科学校附属医院,526020

出　　处：《中国医疗前沿》2012年第20期3-4,共2页China Healthcare Innovation

摘　　要：目的探讨肺癌患者血浆纤维蛋白原和D-二聚体水平变化情况以及其与肺癌患者的病情关系。方法肺癌组患者96例均为我院确诊为肺癌的住院患者,其中57例有转移,39例无转移;肺炎组患者96例;健康对照组96例。分别检测各组血浆纤维蛋白原和D-二聚体浓度,运用SPSS软件进行统计学分析。结果肺癌组患者纤维蛋白原、D-二聚体明显高于肺炎组和健康对照组,肺癌组患者中有转移组高于无转移组,差异有统计学意义(均P<0.05)。肺炎组血中纤维蛋白原、D-二聚体平均水平均高于健康对照组,但差异无显著性(均P>0.05)。结论通过监测血浆纤维蛋白原和D-二聚体浓度有助于判断肺癌患者体内高凝和纤溶状态以及肿瘤转移情况。Objective To explore the level of plasma fibrinogen and D-dimer of people with lung cancer and to find out the association with the state of the disease. Method The patients were selected in our hospital： 96 cases who were definitely diagnosed with lung cancer as lung cancer group, among them 57 cases had been confirmed with metastasis and 39 cases without, 96 cases of pneumonia patients groups Another 96 normal cases were chosed as the control group. The level of plasma fibrinogen and D-dimer were measured respectively. The related statistical analysis was compIeted by SPSS software package. Results The level of plasma fibrinogen and D-dimer in the lung cancer group was significantly higher than that in the pneumonia group and the healthy control group, and in the lung cancer group patients with metastasis were higher than that without metastasis（P〈0.05）, fibrinogen and D-dimer in the pneumonia group were higher than that in healthy control group, but the difference was not significant（P〉0.05）. Conclusion By detecting the level of plasma fibrinogen and D-dimer is helpful to evaluate the state of procoagulation and fibrolysis in the patients with lung cancer.

关 键 词：肺癌 纤维蛋白原 D-二聚体 

分 类 号：R730.3[医药卫生—肿瘤]