维吾尔族、汉族非酒精性脂肪肝与血尿酸的相关性研究  

The associaion of serum uric acid level with prevalence of non-alcoholic fatty liver in Uyghur and Han ethnieities

作　　者：蔡雯[1] 何方平[2] 吴璇[3] 姚华[4] 

机构地区：[1]新疆医科大学护理学院,乌鲁木齐830000 [2]新疆医科大学第一附属医院肝病科 [3]新疆医科大学第四附属医院脑二科 [4]新疆医科大学第一附属医院医学研究院

出　　处：《中华内分泌代谢杂志》2012年第11期890-894,共5页Chinese Journal of Endocrinology and Metabolism

基　　金：国家重点基础研究发展计划（973计划）项目（2012CB722400,2012CB722403）

摘　　要：目的探讨维吾尔族、汉族非酒精性脂肪肝与血尿酸之间的关系。方法采用横断面研究，调查在新疆医科大学第一附属医院体检者4724人，维吾尔族2439人，汉族2285人；所有受试者均进行问卷调查、体重指数、腰围、血压、血糖、血脂、血尿酸等生化检测；将正常范围血清尿酸浓度按四分位分组，尿酸浓度高于正常范围为高尿酸组，分析血尿酸与非酒精性脂肪肝的关系以及高尿酸血症与代谢综合征及其组分的关联性。结果维吾尔族、汉族人群非酒精性脂肪肝检出率分别为26．7％、23．6％，高尿酸血症检出率分别为7．8％、18．2％：维吾尔族人群的尿酸水平低于汉族（P〈0.01），非酒精性脂肪肝组血清尿酸水平高于对照组（P〈0.01）：高尿酸血症组中非酒精性脂肪肝在维吾尔族、汉族人群的检出率为24．0％、19．0％，高于非高尿酸血症组；即使在正常范围内，非酒精性脂肪肝检出率随血清尿酸水平升高而升高。结论维吾尔族人群血尿酸水平与非酒精性脂肪肝发病的关系较汉族人群更为密切。Objective To explore the association of serum uric acid level with non-alcoholic fatty liver disease（ NAFLD ） in Han and Uyghur ethnic groups. Methods A cross-sectional study was performed in the population in 2011 in the First Affiliated Hospital of Xinjiang Medical University. The study included 2 439 Uyghurs and 2 285 Hans with a questionnaire survey, and body mass index（BMI） , waist circumference, blood pressure, blood glucose, blood lipid, and serum uric acid （SUA） level were measured. The participants were divided into 4 groups according to the quartiles of the SUA levels within the normal range, and those with SUA levels above the normal range served as hyperuricemia group. The associations between serum uric acid level and prevalence of non-alcoholic fatty liver, hyperuricemia, and metabolic syndrome （ MS, including each component of MS ） were analyzed. Results Among Uyghurs and Hans, the detection rates of NAFLD were 26.7% and 23.6% respectively, the detection rates of hyperuricemia were 7.8% and 18.2% , and the level of serum uric acid in Uyghur group was lower than that in Han group （ P〈0.01 ）, The detection rate of NAFLD in the hyperuricemia patients was significantly higher than that in non- hyperuricemia group. Among the Uyghurs and Hans, the detection rates of NAFLD in the hyperurieenia patients were 24.0% and 19.9%. The detection rate of NAFLD was positively associated with concentration of serum acid even that within the normal range. Conclusion The relationship between the level of serum uric acid and the prevalence of NAFLD is more evident in Uyghur than that in Han.

关 键 词：非酒精性脂肪肝 血尿酸 维吾尔族 汉族 

分 类 号：R575.5[医药卫生—消化系统]