乳腺癌组织中midkine的表达及临床意义  

Expression and clinical significance of midkne in breast cancer

作　　者：王坤华[1] 王庆苓[1] 来瑞娜[1] 吴永平[1] 

机构地区：[1]徐州医学院病理学教研室,徐州221002

出　　处：《临床与实验病理学杂志》2012年第11期1191-1193,共3页Chinese Journal of Clinical and Experimental Pathology

基　　金：国家自然科学基金(81101493)

摘　　要：目的探讨中期因子(midkine,MK)的表达与乳腺癌临床病理特征的关系。方法采用免疫组化PV两步法检测44例乳腺癌及相应癌旁组织(癌旁2 cm)中MK蛋白的表达,并分析其与不同临床病理特征之间的关系。结果 (1)乳腺癌及相应癌旁组织中MK蛋白的阳性率分别为90.91%(40/44)、11.36%(5/44),差异均具有统计学意义(P<0.05)。(2)MK蛋白在乳腺癌组织中的表达与淋巴结转移相关(P<0.05),与患者年龄、肿瘤大小、病理分级、临床分期无关(P>0.05)。结论 MK蛋白在乳腺癌组织中的表达增高与淋巴结转移相关,提示MK可能成为乳腺癌转移的标记物之一,为乳腺癌的诊断和治疗提供新依据。Purpose To investigate the relationship between the expression of midkine （MK） and clinicopathologic characterics in breast cancer tissues. Methods The expression of MK were detected by PV immunohistochemical technique in 44 samples of breast cancer and para-carcinoma tissues （ para-careinoma 2 era）. Results （ 1 ） The positive expression rate of MK in breast cancer tissue and para-carcinoma tissue were 90. 91% （40/44） and 11.36 % （ 5/44 ）, which the differences are significant （ P 〈 0.05 ）. （ 2 ） The expres- sion of MK in breast cancer were correlated with the lymph node metastasis （ P 〈 0. 05 ）, but unrelated to the age, tumor size, patholo- gy grade, TNM stage （ P 〉 0.05 ）. Conclusion The expression of MK protein increased in breast cancer tissues witch is correlated with the lymph node metastasis. The results suggest that MK can be used as one of the most important makers in predicting the metasta- sis of breast cancer, and to provide a new basis for the treatment of breast cancer.

关 键 词：乳腺肿瘤 中期因子蛋白 临床病理特征 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]