乳腺浸润性导管癌中干细胞关键转录因子FoxD3的表达  

Expression of stem cell key transfer factor FoxD3 in breast invasive ductal carcinomas

作　　者：印永祥[1] 赵华[1] 王嘉园[1] 陈道桢[1] 高琼[2] 张晔[2] 

机构地区：[1]南京医科大学附属无锡妇幼保健院病理科,南京214002 [2]南京医科大学附属无锡妇幼保健院妇科,南京214002

出　　处：《临床与实验病理学杂志》2012年第11期1194-1197,共4页Chinese Journal of Clinical and Experimental Pathology

基　　金：江苏省科教兴卫工程专项经费资助(RC2011033)

摘　　要：目的探讨干细胞关键转录因子FoxD3在乳腺浸润性导管癌(invasive duct carcinomas,IDC)组织中的表达。方法采用免疫组化MaxVision法检测FoxD3、HER-2、Ki-67、ER和PR在79例乳腺IDC组织中的表达,HER-2结果附加荧光原位杂交(fluorescence in situ hybridization,FISH)确诊。结果 FoxD3蛋白表达与患者年龄、病理分级、临床分期、HER-2状态和激素状态无明显相关(P>0.05)。与淋巴结未转移组相比,淋巴结转移组低表达FoxD3蛋白(P<0.05),HER-2和Ki-67表达明显增高。与三阴性乳腺癌(triple negative breast cancer,TNBC)相比,其他型乳腺癌FoxD3表达明显增加。FoxD3蛋白与Ki-67增殖指数无明显相关性。结论 FoxD3低表达可能促进乳腺癌淋巴结转移,有可能成为治疗乳腺癌的重要靶点之一。Purpose To detect expression of stem cell key transfer factor FoxD3 in mammary invasive ductal carcinomas （IDC）. Methods The protein expressions of FoxD3, HER-2, Ki-67, ER and PR in 79 cases of breast IDC were detected by immunohisto- chemistry （MaxVision assay） and statistically analysis. The HER-2 results were additionally confirmed by fluorescence in situ hybrid- ization （FISH）. Results FoxD3 expression level showed no statistical correlation with age, pathological grading, clinical stage, HER-2 and hormone state （P 〉 0. 05）. The expression of FoxD3 and Ki-67 was significantly increased in invasive ductal breast cancer without lymphatic metastasis compared to that in invasive ductal breast cancer with lymphatic metastasis （P 〈 0.05 ）. The expression of HER-2 was significantly increased in invasive ductal breast cancer with lymphatic metastasis compared to that in invasive ductal breast cancer without lymphatic metastasis （P 〈 O. 05）. Compared with TNBC, the expression of FoxD3 was significantly increased in other of invasive ductal breast cancer. The expression of FoxD3 was no associated with Ki-67 （P 〉 0. 05）. Conclusion The decreasing ex- pression of FoxD3 may play an important role in the metastasis of invasive breast cancer. FoxD3 may provide a basis for the develop- ment of a novel therapeutic target in breast cancer.

关 键 词：乳腺肿瘤 浸润性导管癌 FoxD3 HER-2 免疫组织化学 FISH 

分 类 号：R736[医药卫生—肿瘤]