肺硬化性血管瘤的组织发生及p63表达的意义  

The investigation of histogenesis and significance of expression of p63 on pulmonary sclerosing hemangioma

作　　者：张昶[1] 刘海燕[1] 乔海国 吴健[1] 

机构地区：[1]江苏省淮安市第一人民医院病理科,223300 [2]江苏省涟水县人民医院病理科,223200

出　　处：《临床与实验病理学杂志》2012年第11期1243-1245,共3页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的探讨p63在肺硬化性血管瘤(sclerosing hemangioma,SH)中的表达及意义,并探讨SH的组织起源、病理形态学特征、诊断。方法对12例SH作回顾性研究,其中9例行p63、SPB、TTF-1、EMA、CKpan、vimentin、SMA、CgA、Syn和CD34等免疫组化EnVision法标记。结果 SH组织主要表现为实性区、乳头区、血管瘤样区和硬化区等四种结构。瘤细胞主要由立方形和多角形或圆形两种肿瘤细胞组成。免疫组化示8例SH乳头状表面及实性区腺腔样或裂隙样结构衬覆的立方形细胞肿瘤表达p63,所有肿瘤细胞同时表达TTF-1和EMA,立方形肿瘤细胞表达SPB,多角形或圆形肿瘤细胞表达vimentin,仅1例多角形或圆形肿瘤细胞CgA局灶性,Syn弱阳性。结论 p63阳性的立方形肿瘤细胞可能是多潜能的原始呼吸道上皮细胞,它具有多方向分化的能力。p63免疫标记对SH的诊断可能具有重要的价值。Purpose To investigate the histogenesis clinicopathologic characteristic, diagnosis and differentiatial diagnosis of pulmonary sclerosing hemangioma （SH） and its significance of expression of p63 were discussed. Methods 12 cases of pulmonary sclerosing he- mangioma were reevaluated and 9 cases were studied by immunohistochemieal methods. Results SH contained 2 kinds of tumor cel1： polygonal or round tumor cells and euboidal tumor cells and 4 kinds of organization shape ： solid, papillary, hemangiomatic, and scle- rotic pattern. The cuboidal tumor cells expressed p63 （8/9 cases） and expressed SPB, CK, TTF-1, EMA （9/9 eases）, polygonal or round ceils always expresseed vimentin, TFF-1, EMA （9/9 cases）. Conclusions p63 positive euhoidal tumor ceils may he the pluri- potent primary respiratory epithelium, and immunohistochemieal markers of p63 may play an important role in the diagnosis of SH.

关 键 词：肺硬化性血管瘤 P63 组织发生 免疫组织化学 

分 类 号：R730.4[医药卫生—肿瘤]