芳香烃受体与树突状细胞的关系  

The relationship between aryl hydrocarbon receptor and dendritic cells

作　　者：张醇[1] 范霞[1] 梁华平[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所第一研究室,重庆400042

出　　处：《免疫学杂志》2012年第12期1094-1098,共5页Immunological Journal

基　　金：国家青年基金项目(81001320)

摘　　要：DC作为专职的抗原呈递细胞,在启动和调节先天性及适应性免疫应答中发挥关键性作用。芳香烃受体(arylhydrocarbon receptor,AhR)作为配基依赖性活化转录因子,可表达于树突状细胞(dendritic cell,DC)中。AhR与不同配体相结合活化后,可通过对DC的影响调节机体免疫应答。深入研究AhR和DC的关系的为纠正DC功能异常所导致的免疫功能紊乱提供新的思路。本文就AhR与DC来源、分化、成熟以及介导的免疫应答之间的关系作一简要综述。Dendritic cells（DCs）,as professional antigen presenting cells,play a critical role in immune response.While aryl hydrocarbon receptor（AhR）,as a transcription factor,is expressed in dendritic cells（DC）.AhR is activated following binding to ligands and regulates immune response through DC.Therefore,the investigation of the relationship between AhR and DC would provides a new prospect for the recovery of immune system functional disorder induced by DC dysfunction.In this paper,we reviewed the association of AhR with DC resource,differentiation,maturation,and immune response.

关 键 词：AHR DC 免疫应答 

分 类 号：R392.11[医药卫生—免疫学]