干细胞应用研究的重要课题：视网膜母细胞瘤基因通路对干细胞的调控  

An important subject in stem celts research： the regulatory of retinoblastoma pathway for stem cells

作　　者：周伊[1] 王易林[2] 陈大年[1] 

机构地区：[1]四川大学华西医院眼科、分子医学研究中心眼科研究室、世界眼科组织托斯顿韦素研究所,成都610041 [2]重庆三峡中心医院外科

出　　处：《中华眼底病杂志》2012年第6期549-551,共3页Chinese Journal of Ocular Fundus Diseases

摘　　要：干细胞在胚胎发育和维护成年个体细胞的动态平衡中具有重要作用。深入研究胚胎和成体干细胞的调节机制，对于认识肿瘤、变性等多种疾病的发病机制、开发设计新的治疗方法都具有重要意义。视网膜母细胞瘤信号传导通路控制细胞的增生、分化和死亡，该信号传导通路对多种于细胞和祖细胞的生物学行为有重要的调节作用，是未来扩增特定干细胞群体的重要靶通路。Stem cells are crucial for embryonic development and in the maintenance of adult cellular homeostasis. Understanding the regulatory network of stem cells, including embryonic and adult stem cells, will allow us to learn the pathogenesis and possibly design novel approaches to treat many diseases （such as cancer and degeneration）. The retinoblastoma （Rb） pathway controls cellular proliferation, differentiation and death. More and more evidences support an important role of Rb activity in the biology of stem and progenitor cells. Transiently inactivating Rb pathway might favor the expanding of functional stem cell populations, thus have values in the future stem cell applications.

关 键 词：视网膜母细胞瘤 信号传导 病理生理学 干细胞 病理生理学 述评 

分 类 号：R739.72[医药卫生—肿瘤]