中国人群IL-1RN基因VNTR多态性与宫颈癌遗传易感性关系的研究  

Research of Relationship between IL-1RN VNTR Polymorphism and Genetic Susceptibility of Cervical Cancer in Chinese Population

作　　者：黄加忠[1] 李靖[1] 杨学艺[1] 

机构地区：[1]淮阴卫生高等职业技术学校,江苏淮安223300

出　　处：《中国医疗设备》2012年第11期37-39,共3页China Medical Devices

基　　金：国家自然科学基金(81172141)

摘　　要：人类乳头瘤病毒（HPV）感染被认为是宫颈癌的主要致病因素，尽管如此，宿主遗传因素在其易感性方面起的作用已越来越大。白细胞介素1受体拮抗剂（IL—1RN）是一种重要的宿主免疫调节因子，并且对病毒相关疾病的预防至关重要。前期研究IL—1RN基因内含子2的1个86bp的VNTR多态性在宿主免疫反应变异的潜在作用。本文从中国淮安地区采集201名健康妇女和297名宫颈病变妇女的外周血标本，使用病例对照法研究这种多态性在中国宫颈癌中的作用。结果表明病例组1L-1RN等位基因2纯合子显著高于对照组，且发现IL-1RNA2^＊A2纯合子与高级别上皮内瘤样变（HSIL）和ICC的风险增加有关（OR=1.94；95％CI：1．12-3．30；P=0．017）。提示IL—IRNA2与宫颈癌的易感性增加有关，且可能是通过缩短机体免疫反应时间来实现。Human Papitlomavirus （HPV） infection is considered as the main etiological factor of cervical cancer, however, the role of host genetic factors in susceptibility has been increasing. Interleukin 1 receptor antagonist （IL-1RN） is an important regulator of host immunity, and is considered to be crucial for the prevention of diseases associated with virus. Several earlier studies have shown a potential role ofa 86bp VNTR polymorphism within intron 2 of the IL-IRN gene in host immune response variability. This paper investigates the role of this polymorphism in cervical cancer with case-control study by peripheral blood samples from 201 healthy women and 297 women with cervical lesions in Huaian China.The result indicates that IL-1RN allele 2 homozygosis is significantly higher in cases than in controls. In fact, IL-1RN A2^＊A2 homozygote reveals to be associated with an increasing risk of HSIL and ICC （OR=1.94; 95%CI： 1.12-3.30; P = 0.017）. It indicates that IL-1RN A2 is associated with an increasing susceptibility to ICC, which probably realizes by reducing immune response time.

关 键 词：IL—1RN基因 VNTR多态性 宫颈癌 遗传易感性 

分 类 号：R737.33[医药卫生—肿瘤]