中药中真菌毒素检测方法的最新研究进展  

Latest Advancement for Detection Methods of Mycotoxins in Traditional Chinese Medicine

作　　者：冯旭[1,2] 孔维军[1] 杨美华[1] 欧阳臻[2] 

机构地区：[1]中国医学科学院北京协和医学院药用植物研究所,北京100193 [2]江苏大学药学院,镇江212013

出　　处：《世界科学技术-中医药现代化》2012年第5期1944-1952,共9页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：科学技术部国家重大新药创制专项(2009ZX09502-025):中药有害真菌毒素残留物的检测与分析关键技术,负责人:杨美华;科学技术部国家重大新药创制专项(2013ZX09301307-005-005):中药外源性污染物控制技术研究,负责人:孔维军;2008中医药行业科研专项(200807042):中药中真菌及真菌毒素污染分析及检测技术标准研究,负责人:杨美华

摘　　要：真菌毒素是真菌类产生的次级代谢产物,具有致癌、致畸和致突变作用,以及细胞毒性、肾损害、生殖紊乱和免疫抑制等毒性作用。中药在种植、采收、加工、运输和储藏过程中由于操作不当极易污染真菌,进而产生各种真菌毒素,这不仅影响中药的质量和疗效,还会给人体造成重大危害。因此,建立灵敏、准确的分析方法检测中药中真菌毒素的污染水平显得尤为重要和必要。本文对中药中真菌毒素的常见检测方法的最新研究进展进行综述,以期为同类研究提供参考。Mycotoxins are secondary metabolites produced by certain fungi, which can trigger cancers, deformity and mutation, and are greatly harmful to cells, kidney, reproductive system and immune system. In the processes of planting, harvesting, processing, transportation and storage, traditional Chinese medicine （TCM） can be contaminated easily by mycotoxins. Not only could it influence the quality and efficacy of TCM, but also do great harm to human body. Therefore, it seems important and necessary to establish sensitive and accurate methods to detect the mycotoxins in TCM. This paper reviewed the advancement of detection methods for mycotoxins in TCM to provide some references for related studies.

关 键 词：真菌毒素 检测方法 最新进展 

分 类 号：R996.2[医药卫生—毒理学]