GSTM1基因多态性与海南中老年胃癌易感性的关联性研究  

Research on the relationship of the susceptibility to elderly gastric cancer and GSTM1 gene polymorphism in Hainan

作　　者：王文文[1] 杨文明[2] 张云霞[3] 赵蜀崖[1] 

机构地区：[1]海南省人民医院消化内科,海南海口571100 [2]海南医学院07生物技术班 [3]海南医学院理学院

出　　处：《现代预防医学》2012年第23期6273-6274,共2页Modern Preventive Medicine

摘　　要：目的初步研究生物转化酶类谷胱甘肽转硫酶M1(GSMT1)基因缺失多态性与海南中老年人群胃癌易感性的关系。方法收集某院中老年胃癌患者血液DNA130例作为实验组,体检科中老年健康体检者血液DNA138例作为对照组,利用PCR技术对所有的DNA样本进行GSTM1缺失多态性的检测。利用统计学软件SPSS13.0对数据进行统计学分析。结果 GSTM1(-)/GSTM1(+)在实验组中的检出率为29.8%/70.2%,在对照组中的检出率为18.8%/81.2%,两组间的数据经统计学分析差异有统计学意义(χ2=4.538,P=0.033﹤0.05)。结论 GSTM1基因缺失多态性与海南中老年人群胃癌易感性有关,GSTM1(-)可能是海南中老年胃癌患者的易感基因型。OBJECTIVE To investigate the correlation between the deletion polymorphism of GSTM1 and the susceptibility of the elderly gastric cancer in Hainan. METHODS 130 cases of DNA from elderly gastric cancer patients were collected as the experiment group and 138 cases of DNA from the healthy were collected as the control group. The GSTM1 （-） / GSTM1 （＋） polymorphism were detected by PCR. The data were analyzed by Excel and SPSS13.0 software. RESULTS The frequency of GSTM1 （-） / GSTM1 （＋） was 29.8% / 70.2% in the experiment group and 18.8% / 81.2% in the control group which was significantly different according to the statistically analysis （χ^2 = 4.538, P = 0.033﹤0.05）. CONCLUSION The deletion polymorphism of GSTM1 is related to the susceptibility of the elderly gastric cancer, and GSTM1 （-） plays an negative role.

关 键 词：胃癌 海南中老年人群 谷胱甘肽转硫酶M1 

分 类 号：R735.2[医药卫生—肿瘤]