中青年脑梗死患者同型半胱氨酸的检测及其与病情的关系  

Homocysteine detection and its relationship with cerebral infarction in young patients

作　　者：姜岩[1] 王媛博[1] 陈迎[1] 于绘丽[1] 信慧[1] 韩雪[1] 李晓华[2] 

机构地区：[1]齐齐哈尔医学院附属第三医院神经四科,黑龙江齐齐哈尔161002 [2]齐齐哈尔医学院附属第三医院

出　　处：《现代预防医学》2012年第23期6358-6359,6362,共3页Modern Preventive Medicine

摘　　要：目的探讨同型半胱氨酸(Homocysteine,Hcy)与中青年脑梗死患者及其病情的相关性。方法共纳入85例经头颅MRI/CT证实的中青年脑梗死患者,同时从门诊随机抽取90例无动脉粥样硬化病史的人群作为对照组。入院24h内行美国国立卫生院神经功能缺损评分(The National Institutes of Health Stroke Scale,NIHSS)。采用酶联免疫吸附法检测血清HCY水平。结果与正常对照组相比,中青年脑梗死患者的Hcy水平明显增高,差异比较有统计意义(P﹤0.05);中青年脑梗死患者诊断为HH的例数亦高于对照组,差异比较有统计意义(P﹤0.05)。进一步行血清Hcy水平与病情的关系分析结果显示,随着NIHSS评分的严重程度的增加,血清Hcy水平亦随之升高,呈正相关,相关系数为0.92(P﹤0.05);随着NIHSS评分的严重程度的增加,诊断为HH的患者比例亦随之升高,但差异比较无统计学意义(P﹥0.05)。结论血清Hcy水平与中青年脑梗死的发生存在密切相关性,且可以反映脑梗死灶的大小及病情的严重程度。血清Hcy水平与脑梗死的病情呈明显正相关关系。对该类患者的血清Hcy水平需要进行严格的控制,可能降低中青年脑梗死的发生率并改善预后。OBJECTIVE To know Homocysteine （Hcy） detection and its relationship with cerebral infarction in young patients. METHODS 85 young patients confirmed with cerebral infarction by MRI /CT and 90 cases with no atherosclerosis history as the control group were studied. The National Institutes of Health Stroke Scale （NIHSS） was used to test the patients in 24 hours after hospitalization. The serum level of Hcy was detected by ELISA method. RESULTS Compared with the control group, Hcy level in middle-aged and young patients with cerebral infarction was significantly higher （P﹤0.05）; Young and middle-aged cerebral infarction patients were diagnosed as HH were also higher than those in the control group, the difference was statistically significant （P﹤0.05）. NIHSS scores were positively related with the serum level of Hcy, and the correlation coefficient was 0.92 （P﹤0.05）; NIHSS scores increased with the proportion increasing of patients diagnosed as HH, but there was no statistically significant difference （P﹥0.05）. CONCLUSION Serum level of Hcy has close correlation with young and middle-aged cerebral infarction, and it can reflect the size and the severity of the cerebral infarction. Strict control on Hcy levels may reduce the incidence of young and middle-aged cerebral infarction and improve the prognosis.

关 键 词：同型半胱氨酸 中青年 脑梗死 

分 类 号：R743.33[医药卫生—神经病学与精神病学]