单加成C_(60)衍生物对HeLa细胞生长的影响  

Influence of C_(60) Monoadducts on the Growth of Hela Cells

作　　者：程福永[1] 杨新林[1] 朱鹤荪[1] 

机构地区：[1]北京理工大学材料科学研究中心,北京100081

出　　处：《北京理工大学学报》2000年第2期261-264,共4页Transactions of Beijing Institute of Technology

基　　金：国家自然科学基金!59702009

摘　　要：研究单加成C60衍生物对人宫颈癌HeLa细胞生长的影响．合成了C60核酸酯（C1）和C60甘氨酸酯（C2）两个单加成的C60衍生物；制备了C60及两个衍生物的聚乙烯基吡咯烷酮（PVP）水溶液，并利用MTT法研究了它们对人宫颈癌HeLa细胞的作用．C60，C1在不光照及两种光照条件（光源功率分别为100W和300W）下对HeLa细胞的生长均不起作用，而C2在功率为300W的碘钨灯光照时则表现出明显的抑制作用．该结果提示C60衍生物对细胞生长的作用与光敏效应有关，并且与侧链结构也有一定的关系．To study the influence of C6o monoadducts on the growth of Hela cells, two C6o monoadducts: ethyl caboxylic C6o, (C1) and glycinate derivative of C6o, (C2) were prepared; C6o,C1 and C2 were introduced into water with PVP and then their effects on the growth of HeLa cells were studied by MTT assay under different irradiation conditions. Both PVP solutions of C6o and C1 showed no obvious effect on the growth of HeLa cells under any of three irradiation conditions (the power of the light was o W, 1oo W, 3oo W,respectively), while C2 can remarkably inhibit HeLa cells growth when the light power is 3oo W. The effects of C6o derivatives on the cells growth were related to the side chain structure, and were also dependent on the power of the light irradiation.

关 键 词：HELA细胞 光敏效应 单加成碳60衍生物 生长 

分 类 号：R737.330.5[医药卫生—肿瘤] Q26[医药卫生—临床医学]