肾上腺素用于心肺复苏研究进展  

The application of epinephrine in cardio-pulmonary resuscitation:an update study

作　　者：杭晨晨[1] 李春盛[1] 

机构地区：[1]首都医科大学附属北京朝阳医院急诊科,北京100020

出　　处：《中国实用内科杂志》2012年第11期820-823,共4页Chinese Journal of Practical Internal Medicine

摘　　要：肾上腺素——人体内天然存在的儿茶酚胺,兼有拟α和β肾上腺素能活性,具有增加周围血管阻力,提高冠状动脉和脑血管灌注压,促进循环恢复的作用,几十年来一直作为心肺复苏过程中抢救心脏骤停的首选药物。但因受到道德伦理的限制,缺乏大规模的临床随机对照试验研究,肾上腺素的有效性尚未被确定。近些年对肾上腺素运用于心脏骤停可能存在的心脑损害及不良的远期预后倍受争议。文章就近些年肾上腺素与心脏骤停抢救后预后研究进展进行初步的探讨。Epinephrine, the catecholamine naturally in human body, possesses adrenergic activities of α and β, which can increase the resistance of peripheral vessels, improve the perfusion pressures of coronary artery and cerebral vessels, and promote the recovery of circulation. In recent decades, epinephrine has always been a drug of choice for the emergency treatment of cardiac arrest （CA） during cardio-pulmonary resuscitation （CPR）. However, the efficacy of epinephrine remains uncertain due to the lack of massive clinical random control trials under the limitation of ethics. In recent years, epinephrine has been controversial in application in CPR due to its possible damage of heart and brain and the adverse long-term prognosis. In this study,the application of epinephrine and the prognosis after emergency treatment for CA in these years were pri- marily investigated.

关 键 词：肾上腺素 心脏骤停 远期存活率 心肺复苏 周围血管阻力 

分 类 号：R459.7[医药卫生—急诊医学]