超声激励微泡“空化效应”增敏肿瘤化疗现状与进展  

Status and progress of cavitation effect by ultrasound-activated microbubbles in sensitizing tumor chemotherapy

作　　者：许婷婷[1] 吴凤林[1] 

机构地区：[1]南方医科大学附属南方医院超声科,广州市510515

出　　处：《临床超声医学杂志》2012年第11期756-758,共3页Journal of Clinical Ultrasound in Medicine

摘　　要：超声激励微泡所产生的"空化效应"能够介导肿瘤细胞凋亡,实现对特定组织释放药物,以及诱导肿瘤血管的栓塞、抑制肿瘤血管的分化增殖,从而发挥靶向治疗的作用。这一项非侵入性治疗策略开拓了肿瘤治疗的思路,并成为新近超声研究中的热点。现就该策略的研究进展进行简要综述。Cavitation effect by uhrasound-activated microbubbles can mediate tumor ceils necrosis/apoptosis, achieve drug delivery at specific tissue, induce embolization/obstruction of tumor vessels and restrain differentiation or proliferation of tumor vessels. It may offer a new method in the targeted therapy of tumors .Microbubble stimulated by ultrasound as a non-invasive strategy will exploit a new pathway for tumor treatment, and has become a hot topic recently.The status and development of this strategy was reviewed briefly in this article.

关 键 词：超声检查 微泡 肿瘤 化疗 

分 类 号：R739[医药卫生—肿瘤] R445.1[医药卫生—临床医学]