康艾注射液对晚期非小细胞肺癌患者化疗后免疫功能和生活质量的影响  

Clinical study of kang'ai Injection combined with chemotherapy in the treatment of advanced lung cancer

作　　者：郑召鹏[1] 邢时云[1] 杨卫兵[1] 邵青[1] 黄丽斌[1] 吕宏菲[1] 万果[1] 

机构地区：[1]遵义医学院附属医院肿瘤医院,贵州遵义563099

出　　处：《遵义医学院学报》2012年第3期209-212,共4页Journal of Zunyi Medical University

摘　　要：目的观察晚期非小细胞肺癌(Non-small-cell lung carcinoma,NSCLC)化疗同时应用康艾注射液对化疗后免疫功能和生活质量的影响。方法将48例晚期NSCLC患者随机分为治疗组25例,对照组23例。治疗组化疗同时应用康艾注射液,对照组仅给予化疗。化疗方案均选择常规含铂两药联合方案,化疗4个周期。观察两组化疗后免疫功能和生活质量变化。结果 CD3+、CD3+CD4+、CD3+CD8+和T+B+NK、CD19+、NK淋巴细胞百分数和CD4+/CD8+比值比较:治疗组治疗后较治疗前无明显下降,各指标均有所上升,但差异无统计学意义(P>0.05);对照组治疗后各指标呈下降趋势,其中CD3+、CD3+CD4+下降明显,差异有统计学意义(P<0.05)。治疗组生活质量改善率明显高于对照组,组间比较差异有显著性(P<0.05)。治疗组化疗导致的毒副反应轻于对照组,组间比较差异有显著性(P<0.05)。结论康艾注射液配合化疗治疗晚期非小细胞肺癌能减轻化疗免疫功能损伤及毒副反应,改善生活质量。Objective To evaluate the efficacy of Kang＇ai Injection combined with chemotherapy in NSCLC.Methods Patients（n=48） with advanced NSCLC were randomized into 2 groups,25 in treatment group（chemotherapy plus kang＇ai injection）,23 in control group（chemotherapy only）.To compare the quality of life,immune function and adverse reactions of chemotherapy between two groups.Results The percentages of CD3＋、CD3＋CD4＋ reduced significantly in control group（P0.05）,but increased nonsignficant in treatment group.The improvement rate of quality of life in the treatment group was significantly higher than that of the control group with statistical difference between the two groups.The adverse reactions of chemotherapy in the treatment group were milder than those in the control group,showing statistical difference between the two groups.Conclusion Kang＇ai Injection combined with chemotherapy can significantly improve patients＇quality of life and immune function and reduce the adverse reactions of chemotherapy.

关 键 词：康艾注射液 非小细胞肺癌 免疫功能 生活质量 

分 类 号：R743.2[医药卫生—神经病学与精神病学]