坦度螺酮治疗伴有焦虑的功能性消化不良的临床研究  

Clinical study on efficacy of tandospirone in treatment of functional dyspepsia with anxi- ety

作　　者：熊小强[1] 陈焕清[2] 李楚强[1] 陈其奎[1] 

机构地区：[1]中山大学孙逸仙纪念医院消化内科,广州510120 [2]中山大学孙逸仙纪念医院预防保健科,广州510120

出　　处：《国际医药卫生导报》2012年第22期3273-3275,共3页International Medicine and Health Guidance News

摘　　要：目的观察坦度螺酮治疗伴有焦虑的功能性消化不良的临床疗效。方法对消化专科门诊的功能性消化不良患者，以Zung的焦虑自评量表（ASA）进行筛选，积分达50分以上的57例患者纳入研究并随机分为治疗组29例和对照组28例，对照组予曲美布丁加潘妥拉唑常规治疗，治疗组加用枸橼酸坦度螺酮胶囊，共治疗6周。根据两组治疗前后症状总积分和ASA积分变化判断临床疗效。结果治疗组总有效率达89．7％，明显高于对照组的46．2％。结论坦度螺酮治疗伴有焦虑的功能性消化不良临床疗效显著。Objective To investigate the clinical efficacy of tandospirone in treatment of func- tional dyspepsia with anxiety. Methods The digestive out patients with functional dyspepsia were screened by Zung Self-rating Anxiety Scale （ASA）. 57 patients with more than 50 ASA points were randomly divided into two groups, the treatment group with 29 cases received with tandospirone citrate capsules combined with conventional treatment, the control group with 28 cases received conventional treatment oral trimebutine maleate and Pantoprazole, for a total of 6 weeks. The clinical efficacy was determined according to the changes of symptoms and ASA after treatment. Results The total symptoms score of treatment group was significantly lower than that of the control group （P〈 0.01）, ASA score was also significantly lower than that of the control group （P〈 0.01）, the total effective rate of treatment group （89.7%） was also significantly better than that control group （46.2%） （P〈 0.01）. Conclusion Tandospironeis is very effective in treat- ing functional dyspepsia with anxiety

关 键 词：坦度螺酮 功能性消化不良 焦虑 

分 类 号：R57[医药卫生—消化系统]