膀胱尿路上皮癌CD44v2的表达及临床意义  

Expression and significance of CD44v2 in transitional cell carcinoma of bladder

作　　者：王永翔 赵立明 赵小东 刘学军 任玉林 李少君 

机构地区：[1]兰州甘肃省第二人民医院泌尿外科,甘肃730000

出　　处：《国际泌尿系统杂志》2012年第6期743-746,共4页International Journal of Urology and Nephrology

摘　　要：目的探讨CD44v2在膀胱尿路上皮癌中的表达及其与临床病理的相关性。方法应用免疫组织化学技术检测60例膀胱尿路上皮癌和10例正常膀胱黏膜CD44v2蛋白的表达。结果CD44v2蛋白在正常膀胱粘膜上皮无表达，在60例膀胱尿路上皮癌中阳性表达是25例（41．7％），阳性表达率与肿瘤的病理分级，TNM分期显著相关，而与肿瘤的复发，数量无关。结论CD44v2可作为判断膀胱尿路上皮癌分级，分期的一个参考指标。Objectives To investigate the expression of CIM4v2 protein and their significance in human bladder transitional cell carcinoma. Methods Immunohistochemistry was used to detect the expression of CD44v2 protein in 60 cases of bladder transitional cell carcinoma and 10 subjects of normal bladder mucosa. Results CD44v2 protein was negative in all normal bladder mucosa. The positive expression of CD44v2 protein was 25 cases （41.7%）. positive rate was correlated with high pathological grades and TNM stages, but no significant difference was observed in recurrence and number of tumor. Conclusions CD44v2 could be useful indicator for the assess- ment of pathological grades and TNM stages of bladder transitional cell carcinoma.

关 键 词：癌 移行性细胞 膀胱肿瘤 抗原 CD44 

分 类 号：R737.14[医药卫生—肿瘤]