盐酸拓扑替康联合顺铂治疗上皮性卵巢癌的临床研究  

Efficacy and toxicity of topotecan hydrochloride plus cisplatin in treatment of epithelial ovarian cancer

作　　者：刘新红 黄冬梅[2] 

机构地区：[1]河南省许昌县人民医院妇产科,461000 [2]郑州大学第二附属医院妇产科

出　　处：《中国临床研究》2012年第11期1044-1046,共3页Chinese Journal of Clinical Research

摘　　要：目的探讨盐酸拓扑替康联合顺铂治疗上皮性卵巢癌的疗效及毒副反应。方法将手术后经病理检查确诊为Ⅱ～Ⅳ期上皮性卵巢癌的68例患者按入选时间顺序分为2组:治疗组与对照组,每组34例。治疗组给予顺铂90 mg/m2,静脉滴注,d1;盐酸拓扑替康0.8 mg/m2,d1～5。对照组给予顺铂90 mg/m2静脉滴注,d1;环磷酰胺800 mg/m2静脉注射,d1。2组患者均以20 d为1疗程。5～7个疗程后评价疗效。结果临床疗效:治疗组完全缓解10例,部分缓解16例,有效率为76.5%;对照组完全缓解5例,部分缓解14例,有效率为55.8%。治疗组与对照组有效率比较差异有统计学意义(P<0.05)。毒副反应:发生Ⅲ～Ⅳ度骨髓抑制的患者,治疗组16例(47.1%),对照组为13例(38.2%),2组毒副反应发生率差异无统计学意义(P>0.05)。结论盐酸拓扑替康联合顺铂是治疗上皮性卵巢癌的有效方案,临床疗效较好,安全性高,其不良反应可控制,患者可耐受。Objective To study the therapeutic effects and adverse effects of topotecan hydrochloride plus cisplatin in treatment of epithelial ovarian cancer in order to a reference for choosing therapeutic regimen of epithelial ovarian cancer. Methods A total of 68 eligible patients with Ⅱ - IV stage epithelial ovarian cancer verified by pathology were enrolled in this study. The patients were divided into experimental group and control group （ n = 34 each） according to eligible time sequence. The patients in experimental group were treated with intravenous infusing topotecan hydrochloride ,0.8 mg/m2 every day for 5 days and intravenous infusing cisplatin 90 mg/m2 on the first day;The patients in Control group were treated with intravenous injecting cyclophosphamide,800 mg/m2 on the first day and intravenous infusing cisplatin 90 mg/m2 on the first day. The courses of two groups all were 20 days. After 5 - 7 courses, the therapeutic effects and adverse effects were evalua- ted. Results In the experimental group, complete remission （CR）was seen in 10 cases;partial remission（PR） was seen in 16 cases;the effective rate was 76.5%. In the control group, CR was seen in 5 cases;PR was seen in 14 cases; the effective rate was 55.8%. There was a significant difference in effective rate between the experimental group and the control group（ P 〈 0.05 ）. The common toxicity was grade Ⅲ - IV myelosuppression in two groups. There was no significant difference in toxicity between experimental group and control group （47.1% vs 38.2%, P 〉 0.05 ）. Conclusions Topotecan hydrochloride plus cisplatin is an effective regimen for the treatment of epithelial ovarian cancer with a good therapeutic effects,high safety and tolerable adverse effects.

关 键 词：盐酸拓扑替康 顺铂 上皮性卵巢癌 化疗 

分 类 号：R737.31[医药卫生—肿瘤]