瘦素受体基因3057G／A多态性对老年抑郁症患者血清瘦素水平的影响  

Effects of polymorphisms of leptin receptor gene 3057 G/A on serum leptin level of senile depressive patients

作　　者：刘玉局 马海波[2] 赵蓓[1] 刘阳[3] 袁勇贵[4] 

机构地区：[1]镇江市第四人民医院精神科,镇江212001 [2]江苏大学临床医学院 [3]南京医科大学脑科医院研究所 [4]东南大学附属中大医院心理精神科

出　　处：《中华行为医学与脑科学杂志》2012年第11期1014-1016,共3页Chinese Journal of Behavioral Medicine and Brain Science

摘　　要：目的探讨瘦素受体基因3057G／A多态性对老年抑郁症患者血清瘦素（1eptin）水平的影响。方法采用放射免疫法对10例伴Ⅱ型糖尿病及47例不伴Ⅱ型糖尿病的老年抑郁症患者和35例正常老年人的血清瘦素浓度进行测定；采用聚合酶链式反应-限制性片段长度多态性技术，检测瘦素受体基因3057G／A多态性和等位基因分布频率。结果（1）3组瘦素受体基因3057G／A多态性位点等位基因和基因型分布频率之间差异无显著性（P均〉0．05）。（2）伴有和不伴有Ⅱ型糖尿病的老年抑郁症组血清瘦素浓度[（41．65±28．19）ng／ml，（25．56±21．04）ng／ml]显著高于正常老年人[（10．84±9．16）ng／ml]（均P〈0．05）；伴有Ⅱ型糖尿病的老年抑郁症组血清瘦素水平又明显高于不伴有糖尿病的抑郁症组（P〈0．05）。（3）携带AA型伴Ⅱ型糖尿病的老年抑郁症患者血清瘦素水平显著高于携带AA型的无糖尿病患者；携带AA型与AG／GG型的无糖尿病的老年抑郁症患者血清瘦素水平之间无显著差异（P〉0．05）；携带AA型与AG／GG型的对照组之间血清瘦素水平无明显差异（P〉0．05）。结论老年抑郁症存在瘦素分泌异常增高，伴Ⅱ型糖尿病患者更为明显；血清瘦素水平与Ⅱ型糖尿病之间存在关联，与瘦素受体基因3057G／A多态性无关联，Ⅱ型糖尿病与瘦素受体基因3057G／A多态性亦无关联性。Objective To investigate the relation of serum leptin level in senile depressive patients with type 2 diabetes and polymorphisms of leptin receptor gene 3057 G/A. Methods 10 senile depressive patients with type 2 diabetes and 47 senile depressive patients without type 2 diabetes were selected for the study. Leptin levels were determined by radioimmunoassay. Genomitic DNA were obtained by phenol/chloroform method. Leptin receptor gene 3057 G/A polymorphisms and allele frequencies were determined with the polymerase chain reaction and restricted fragment length polymorphism assay. Results （ 1 ） The differences of lepton, receptor genotypes and allele distribution in the 3 groups were not found （ all P 〉 0.05 ）. （ 2 ） Serum leptin level in senile depressive patients with type 2 diabetes and without type 2 diabetic patients （ （41.65 ± 28.19）ng/ml, （25.56 ± 21.04 ）ng/ml） were significantly higher than the normal people （ （10.84 ± 9.16 ）ng/ml ） （all P 〈 0.05 ）. Serum leptin level in senile depressive patients with type 2 diabetes were significantly higher than without type 2 diabetic patients （P 〈 0.05 ）. （3） The serum leptin level in genotype AA senile depressive patients with type 2 diabetes were significantly higher than genotype AA patients without type 2 diabetes. The differences of the serum leptin levels in genotype AA senile depressive patients without type 2 diabetes and genotype AG/GG patients without type 2 diabetes were not found（P 〉 0.05）. The differences of the serum leptin level in genotype AA and genotype AG/GG in normal groups were not found（P 〉 0.05）. Conclusion Senile depressive patients have higher serum leptin leyel. The serum leptin lev- el is higher,especially with type 2 diabetes. Serum leptin level is related to type 2 diabetes. Serum leptin level is not related to the polymorphisms of leptin receptor gene 3057 G/A. Type 2 diabetes are not related to polymor- phisms of leptin receptor gene 3057 G/A.

关 键 词：抑郁症 老年人 瘦素 瘦素受体基因 多态性 糖尿病 

分 类 号：R749.4[医药卫生—神经病学与精神病学]