复方丹参滴丸对豚鼠离体心脏心电图的影响  

Effects of Compound Danshen Dropping Pill on electrocardiogram in isolated hearts of guinea pigs

作　　者：李凌艳[1,2] 赵颖[1] 王平[1,2] 郭治昕[2] 孙鹤[1,2] 

机构地区：[1]天津大学药物科学与技术学院,天津300072 [2]天津天士力集团研究院,天津300410

出　　处：《中草药》2012年第11期2236-2241,共6页Chinese Traditional and Herbal Drugs

基　　金：国家"重大新药创制"科技专项(2010ZX09401-406)

摘　　要：目的观察复方丹参滴丸及其组成药物丹参、三七对豚鼠离体心脏心电图的影响,研究其心脏毒性作用。方法应用Langendorff离体豚鼠心脏灌流装置,将复方丹参滴丸浸膏和丹参浸膏(给药质量浓度均以丹参素计)、三七浸膏(给药质量浓度以人参皂苷Rg1计)均按3、0.3、0.1、0.03μg/mL灌注,观察离体豚鼠心脏心电图的变化。结果复方丹参滴丸浸膏和丹参浸膏对豚鼠离体心脏心电图无明显影响,三七浸膏在低质量浓度(0.3、0.1、0.03μg/mL)对豚鼠离体心脏心电图没有影响,但在3μg/mL时可轻微延长PR、RR间期,减慢心率,与对照相比差异显著(P<0.05)。3种药物对校正后的QT间期(QTc)及T波峰到T波结束间期(Tp-e)均无显著影响。结论复方丹参滴丸及其组成药物丹参、三七在实验质量浓度范围内不诱发心室肌细胞复极化延长及严重心律失常。Objective To observe the effects of Compound Danshen Dropping Pill （CDDP） and its components （Danshen, Salvia miltiorrhiza and Sanqi, Panax notoginseng） on electrocardiogram （ECG） in isolated hearts of guinea pigs to study its cardiotoxicity. Methods By using the Langendorff device for isolated hearts of guinea pigs, CDPP extract, Danshen extract （in Danshensu juice）, and Sanqi extract （in ginsenoside Rgl） at different concentration （3, 0.3, 0.1, and 0.03 ~tg/mL） were perfused into the isolated hearts of guinea pigs, respectively, and then the changes of ECG in the isolated hearts were observed. Results CDPP extract and Danshen extract had no statistically significant changes of ECG, while Sanqi extract at the low concentration induced no significant changes of ECG, but the dose of 3 μg/mL induced a significant change and weak increase of R-R and P-R intervals, and decreased heart rate （P 〈 0.05）. There was no significant effect of the three extracts on both QTc and Tp-c intervals. Conclusion CDPP and its components, Danshen and Sanqi at the tested concentration range, have no potential for delaying the ventricular repolarization or can not induce the severe arrhythmia in isolated hearts of guinea pigs.

关 键 词：复方丹参滴丸 丹参 三七 心电图 离体心脏灌流 心室肌复极化 

分 类 号：R965.3[医药卫生—药理学]