后程加速超分割放疗非小细胞肺癌的近期疗效评价  

Short-term results for inoperable stage Ⅲnon-small cell lung cancer treated with late-course accelerated hyperfractionation radiotherapy

作　　者：曹卡加[1] 黄惠英[1] 刘国贞[1] 冼超贵[1] 涂明耻[1] 毛志达[1] 

机构地区：[1]中山医科大学肿瘤防治中心放疗科,广东广州510060

出　　处：《癌症》2000年第3期262-264,共3页Chinese Journal of Cancer

摘　　要：目的 :评价后程加速超分割放射治疗不能手术Ⅲ期非小细胞肺癌的疗效。方法 :从 1996年 8月至1999年 2月 ,经病理组织学或细胞学确诊的 70例不能手术的Ⅲ期非小细胞肺癌随机分为常规分割照射组 (常规组 )和后程加速超分割照射组 (后加速组 )。常规组采用常规分割照射 ,总剂量 6 8～ 72Gy/ 34～ 36次 ,共 7～ 7 5周。后加速组先用常规分割照射 40Gy ,后改用加速超分割照射 (1 5Gy/次 ,2次 /日 ) ,总剂量 70Gy/ 40次 / 6～ 6 5周。用 χ2 比较两组病人的有效率和急性放射反应。结果 :3例病人因放疗期间出现远处转移而退出研究。放疗后 2个月 ,常规组病人CR 6例 (18 2 % ) ,PR 16例 (48 5 % ) ,有效率为 6 6 7% ;而后加速组CR 10例 (2 9 4% ) ,PR 2 0例(5 8 8% ) ,有效率为 88 2 % ,两组有效率比较有显著差异 (P <0 0 5 )。两组Ⅱ度急性放射性气管炎和食道炎的发生率无显著差异。结论 :后程加速超分割放疗能提高不能手术Ⅲ期非小细胞肺癌的近期疗效 。Objective: To evaluate the clinical efficacy of latecourse accelerated hyperfractionation (LCAH) radiotherapy in inoperable stsge Ⅲnonsmall cell lung cancer (NSCLC)Methods: From August 1996 to February 1999, 70 patients with inoperable stage ⅢNSCLC were randomized into two groups: conventional fractionation(CF) and LCAH35 patients in CF group received a fraction of 2Gy daily, 5 days perweek, to the total dose of 68～72Gy/ 3436fx/7～75Weeks35 patients in LCAHF group weretreated with the same fractionation as CF group to the dose of 40Gy, and then followed by LCAHF radiotherapy:15Gy,twice daily,with the interval of 6～8hours between fractions, to the total dose of 70 Gy/40f×6～65 weeksχ2 was used to compare overall responses of the groupsResults: 3 patients were cancelled because of distant metastasis during radiotherapyOverall response was882%in LCAH group, with CR 10 cases and PR 20 cases, as contrast to 667 %in CF group, with CR 6 cases and PR 16 cases (P< 005)There was no significant difference in the incidence of radiationinduced acute bronchitis and esophagitis between two groups (P >005)Conclusions: The overall responses can be improved by LCAH radiotherapy for inoperable stage ⅢNSCLCThe acute reactions induced by LCAH were tolerable to all patients

关 键 词：非小细胞肺癌 放射疗法 后程加速 超分割照射 

分 类 号：R734.2[医药卫生—肿瘤]