检测肿瘤患者IGF-和TGF-α水平的临床意义  

Clinical significance of detection of IGF-Ⅱ and TGF-α in patients with cancer

作　　者：徐军[1] 罗南萍[1] 黄象娟[2] 杨道理[1] 

机构地区：[1]济南军区总医院免疫科,山东济南250031 [2]山东省卫生学校生化教研室,山东济南250031

出　　处：《免疫学杂志》2000年第2期132-133,共2页Immunological Journal

摘　　要：目的为了解生长因子对机体肿瘤细胞的作用。方法用放射免疫分析法检测了肺癌、胃癌、肝癌及肝硬化患者血清中 IGF- 和 TGF- α水平 ,并与术后进行比较。结果肺癌、胃癌和肝癌患者血清中 IGF- 和 TGF- α水平都明显高于正常人 (P<0 .0 1) ;术后两种细胞因子水平与术前各癌症组比明显下降 (P<0 .0 1)。肝硬化时与正常人比 IGF- 明显升高 (P<0 .0 1) ,TGF- α无明显改变。肝硬化组两种细胞因子均非常明显的低于肝癌组 (P<0 .0 1)。结论检测患者血清中 IGF- 和 TGF- α水平 ,有助于癌症的临床诊断和预后观察。Objective To investigate the effects of growth factors on cancer cells.MethodsSerum IGF Ⅱ and TGF α were detected in patients with lung cancer,gastric cancer,hepatic cancer and cirrhosis by immunoassay with comparision to those in patients after operations.ResultsSerum IGF Ⅱ and TGF α in patients with lung cancer,gastric cancer and hepatic cancer were significantly higher than those in normal controls( P <0.01);Compared with those in the groups before operations the serum levels of these two cytokines decreased dramatically in patients after operations( P <0.01).IGF Ⅱ in patients with cirrhosis increased significantly compared with those in normal subjects( P <0.01) while TGF α showed no difference in these two groups.IGF Ⅱ and TGF α in cirrhosis group were significantly lower than those in hepatic cancer group( P < 0.01 ).Conclusion Detection of serum IGF Ⅱ and TGF α was of help to both clinical diagnosis and prognostic observation of cancer. [

关 键 词：IGF-Ⅱ TGF-Α 肿瘤 放射免疫分析 

分 类 号：R730.4[医药卫生—肿瘤]