银杏叶制剂对蛛网膜下腔出血早期大鼠脑缺血的影响  

Effect of Ginkgo biloba extract on cerebral ischemia during early stage of subarachnoid hemorrhage in rats

作　　者：孙保亮[1] 夏作理[1] 杨明峰[1] 葛宝林[2] 

机构地区：[1]泰山医学院附属医院微循环研究所,山东泰安271000 [2]青岛大学医学院病理生理教研室,山东青岛266021

出　　处：《中国病理生理杂志》2000年第3期266-268,共3页Chinese Journal of Pathophysiology

摘　　要：目的 :探讨银杏叶制剂 (GBE)对蛛网膜下腔出血 (SAH)早期缺血性脑损伤的防治作用。方法 :对假手术组 (SO组 )、SAH组和SAH +GBE组大鼠检测 2 4h内局部脑血流量 (rCBF)、脑组织内皮素 - 1(ET - 1)含量和Ca含量改变 ,并对海马CA1区组织作光镜检查。结果 :SAH组于术后rCBF迅速而持续降低 ,脑组织ET - 1含量和Ca含量在诱导SAH 1h后均显著高于SO组 ,3d后海马CA1区神经元明显受损。SAH +GBE组的上述改变均较轻。结论 :GBE可减轻SAH后缺血性脑损伤。AIM: To investigate the effect of Ginkgo biloba extrac (GBE) on cerebral ischemia during early stage of subarachnoid hemorrhage (SAH). METHODS: Noncraniotomy models of SAH in Wistar rats were used and animals were divided into sham-operated group, SAH group and SAH+GBE group. Dynamic change of regional cerebral blood flow (rCBF) was detected. Brain endothelin-1(ET-1) and calcium contents were also determined at different time point during 24 hours after the operation. Pathological change of neurons of hippocampus CA1 region was observed. RESULTS: In SAH group, rCBF decreased immediately and persistently after induction of SAH. Values of brain ET-1 content and calcium content at 1 hour, 6 hours and 24 hours were significantly higher than those in sham-operated group. Neurons of hippocampus CA1 region were damaged severely 3 days after onset of SAH. Above abnormal changes in SAH+GBE group were much slighter than those in SAH group. CONCLUSION: GBE may relieve cerebral ischemic damage after SAH.

关 键 词：蛛网膜下腔出血 脑缺血 大鼠 银杏叶制剂 

分 类 号：R743.350.6[医药卫生—神经病学与精神病学] R743.310.5[医药卫生—临床医学]