过量碘对中枢神经系统影响的实验研究  

The experiment Study of the effect of excess iodine on the level of nitric oxide synthase and Nitric oxide in nervous central system

作　　者：杨长春[1] 尹桂山[1] 朱惠民[2] 刘军需[3] 李娜 

机构地区：[1]河北医科大学生化教研室,石家庄050017 [2]河北医科大学公共卫生学院 [3]河北医科大学实验动物中心 [4]中国人民解放军白求恩军医学院

出　　处：《中国地方病防治》2000年第2期65-67,共3页Chinese Journal of Control of Endemic Diseases

摘　　要：目的研究过量碘对中枢神经系统的影响。方法本实验分为三组，适碘组、过碘Ⅰ组，过碘Ⅱ组，分别以含碘量为５０μｇ／Ｌ、５０００μｇ／Ｌ、１０μｇ／Ｌ蒸馏水及普通饲料喂养豚鼠６个月，分别测定大脑皮质及海马组织一氧化氮和酶活性及一氧化氧含量。结果过碘组大脑皮质及海马组织一氧化氮和酶活性及一氧化氮含量较适碘组明显降低（Ｐ＜０．０１），但两过碘组间一氧化氮和酶活性及一氧化氮含量比较无明显差异（Ｐ＞０．０５）。结论过量碘可以引起大脑皮质、海马组织一氧化氮和酶活性及一氧化氮含量的降低进而对中枢神经系统造成损伤，影响学习记忆与智力。Objective To Study the effect of excess iodine on central nervous system. Method Gumea pigs were divided into three groups at random.The animals of suitable group thank suitable water(50μg/L),the ones of group of ex- cess iodme Ⅰ drank excess iodine water(5000μg/L),and the ones of group of excess iodine Ⅱ drank excess iodine water (10 000μg/L), the experiment was carried out for 180days. The level of NOS and NO in cortex, hippocampus was detected respectively Result Compared with that in suitable group, the level of NOS and NO m cortex, hippocampus was decreased in excess iodine group(P < 0.01),hot there are no differences in two excess iodine groups(P > 0.05). Conclusion ex- cess iodine may lead to the level of NOS and NO in cortex, hippocampus decreased, which may affect nervous nervous system and eventually affect leaning, leaning and intelligence.

关 键 词：碘 一氧化氮 中枢神经系统 学习 记忆 

分 类 号：R151[医药卫生—营养与食品卫生学]