高压氧治疗前交通动脉瘤术后认知功能障碍的效果分析  

Effect of hyperbaric oxygen theraphy on cognitive dysfunction after surgery in patients with anterior communicating artery aneurysms

作　　者：张香菊[1] 王强[1] 陈广鑫[2] 徐伦山[2] 

机构地区：[1]第三军医大学大坪医院野战外科研究所高压氧科,重庆400042 [2]第三军医大学大坪医院野战外科研究所神经外科,重庆400042

出　　处：《中国临床神经外科杂志》2012年第11期651-652,共2页Chinese Journal of Clinical Neurosurgery

摘　　要：目的探讨高压氧治疗(HOT)前交通动脉瘤患者术后认知功能障碍的效果。方法 50例前交通动脉瘤术后出现认知功能障碍患者,随机分为HOT组(26例)和对照组(24例)。两组患者治疗前及治疗后30d均采用简明精神状态检查量表(MMSE)和日常活动能力量表(ADL)评估认知功能。结果 HOT组治疗前后MMSE评分分别为(23±4.1)分和(28±3.2)分,两者差异显著(P<0.05)。对照组治疗前后MMSE评分分别为(22±2.3)分和(24±2.1)分,差异显著(P<0.05)。HOT组治疗前后ADL评分分别为(47±2.3)分和(24±1.2)分,两者差异显著(P<0.05)。对照组治疗前后ADL评分分别为(46±4.23)分和(37±2.4)分,两者差异显著(P<0.05)。治疗后HOT组MMSE、ADL评分与对照组比较,均差异显著(P<0.05)。结论早期HOT可有效改善前交通动脉瘤患者术后认知功能障碍。Objective To explore the cause of cognitive dysfunction, effect of hyperbaric oxygen therapy （HOT） on cognitive dysfunction and its mechanism after surgerya in the patients anterior communicating artery aneurysms （ACoAA）. Methods Fifty patients with cognitive dysfunction after the surgery for ACoAA were randomly divided into HOT treatment group （26 cases） and conventional treatment group （24 cases）. The cognitive function was determined by mini-mental state examination （MMSE） and activities of daily life （ADL） before and 30 days after the treatment in all the patients. Results MMSE scores were （23±4.1） and （28±3.2） points respectively before and 30 days after HOT in HOT group. The MMSE scores were （22±2.3） and （24±2.1） points respectively before and 30 days after the treatment in the conventional treatment group. ADL scores were （47±2.3） and （24± 1.2） points respectively before and 30 days after the HOT in HOT group. ADL scores were （46±4.23） and （37±2.4） points respectively before and 30 days after the treatment. There were significantly differences in MMSE and ADL scores 30 d after the treatment between both the HOT and conventional treatment groups （P〈 0.05）. Conclusion The cognitive dysfunction after the surgery may be improved by HOT in the patients with ACoAA.

关 键 词：前交通动脉瘤 认知功能障碍 高压氧 

分 类 号：R743.9[医药卫生—神经病学与精神病学] R459.6[医药卫生—临床医学]