帕瑞昔布钠对骨癌症痛大鼠痛觉超敏和骨质破坏的影响  

EFFECTS OF PARECOXIB SODIUM ON ALLODYNIA AND BONE DESTRUCTION in BONE CANCER PAIN RATS

作　　者：夏辉[1] 王煜[1] 张登文[1] 徐林[1] 田玉科[1] 王学仁[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院麻醉科,武汉430030

出　　处：《中国疼痛医学杂志》2012年第11期675-677,681,共4页Chinese Journal of Pain Medicine

基　　金：教育部博士点基金新教师项目资助课题(编号:20070487131);湖北省卫生厅青年科技人才基金(编号:QJX2008-1)资助

摘　　要：目的:探讨选择性环氧化酶2(cycloxygenase-2,COX-2)抑制剂帕瑞昔布钠对骨癌症痛大鼠痛觉超敏及肿瘤骨骨质破坏的影响。方法:雌性SD大鼠30只,通过在右侧胫骨骨髓腔内接种Walker 256大鼠乳腺癌细胞制作成骨癌症痛(bone cancer pain,BCP)模型,随机分为5组。一组为单纯骨癌症痛组,另外4组分别在模型制作后第6天、第10天、第15天、第20天开始给予帕瑞昔布钠,连续三天,测定大鼠机械缩爪阈值。并在第23天行HE染色观察大鼠右侧胫骨骨质破坏情况。结果:与单纯骨癌症痛组比较,注射帕瑞昔布钠后骨癌症痛大鼠机械缩爪阈值均明显升高;而且骨质破坏较轻,第6天开始给药组效果最明显(P<0.05)。结论:帕瑞昔布钠缓解癌症痛的痛觉超敏,减轻骨质破坏,并且可以延缓痛觉超敏的发生。Objective： To observe the effects of parecoxib sodium on allodynia and bone destruction in bone cancer pain（BCP） rats.Methods： Thirty female SD rats were established as BCP models by implanting the rat mammary carcinoma cells Walker 256 into right tibial intramedullary space.The BCP rats were randomly divided into 5 groups.One group was pure BCP group.The other four groups were injected with parecoxib sodium（COX-2 inhibitor） on the 6th day,10th day,15th day,20th day after implanting Walker 256 cells for three consecutive days respectively.Changes of pain behavior were assessed by mechanical withdrawal threshold（MWT） before and after administration of parecoxib sodium.The rats were sacrificed on 23th day and tumor-bearing tibia was observed after hematoxylineosin（HE） staining.Results： After administration of parecoxib sodium,the MWT of rats were significantly higher than that of the pure BCP rats（P 0.05）,and bone destruction of tumor-bearing tibia was reduced simultaneously,especially in d 6 group.Conclusion： Parecoxib sodium attenuates allodynia and reduces bone destruction in BCP model rats simultaneously.

关 键 词：环氧化酶2 前列腺素 帕瑞昔布钠 骨癌症痛 痛觉超敏 

分 类 号：R738[医药卫生—肿瘤]