从雷帕霉素与肝癌的关系浅谈转化医学的研究思路  

Translational research of the relationship between rapamycin and hepatocellular carcinoma

作　　者：梁廷波[1] 白雪莉[1] 陈伟[1] 

机构地区：[1]浙江大学医学院附属第二医院肝胆胰外科,杭州310009

出　　处：《中华消化外科杂志》2012年第6期497-499,共3页Chinese Journal of Digestive Surgery

基　　金：国家自然科学杰出青年基金（30925033）;国家自然科学基金（81171184）

摘　　要：目前，我国大多数医学科研的目的仅仅放在研究本身，偏离了应有的轨迹和方向。一方面，许多从事基础医学研究者缺乏临床医学的背景，对临床工作中需要解决的问题和疾病不了解，其研究成果无法与临床结合；另一方面，大多数临床医师每天忙于医疗工作而无暇顾及科学研究，所采用的“经典”和“成熟”的药物和技术未必完全正确。Translational medicine is a new concept in China. It sets up a bridge between basic research and clinical work, and aims to transfer the basic study results to clinical prac- tice as soon as possible. It is necessary for a surgeon to master the research idea of translational medicine in order to be expert in science and technique. Many unsolved clinical problems could be found in routine work, which is an advantage for trans- lational medicine research. How to raise questions in routine clinical work and get these questions resolved in laboratory, and then apply the results to clinical work is a demand for surgeons nowadays. In this article, the research idea of translational med- icine is introduced based on an example of the research on the relationship between rapamycin and hepatocellular carcinoma.

关 键 词：肝肿瘤 雷帕霉素 转化医学 肝移植 

分 类 号：R735.7[医药卫生—肿瘤]