持续静滴顺铂与口服依托泊甙治疗晚期非小细胞肺癌的临床观察  

Clinical Observations of Advanced Non Small Cell Lung Cancer Patients Treated with Continuous Infusion of Cisplatin and Oral Etoposide

作　　者：李京[1] 黎杏群[1] 李家邦[1] 梁清华[1] 袁君[2] 王小宜[3] 

机构地区：[1]湖南医科大学附属湘雅医院中西医结合研究所,长沙410008 [2]湖南医科大学附属湘雅医院放疗科,长沙410008 [3]湖南医科大学附属湘雅医院放射科,长沙410008

出　　处：《肿瘤防治研究》2000年第2期144-145,共2页Cancer Research on Prevention and Treatment

摘　　要：目的　探讨持续静滴顺铂与口服依托泊甙 (VP - 16 )治疗非小细胞肺癌 (NSCLC)。方法　 6 1例晚期NSCLC随机分为治疗组 (33例 )、对照组 (2 8例 )。对照组予常规EP方案。治疗组予顺铂 2 0mg/m2 /日持续静滴 4天及VP - 16胶囊 5 0mgBid× 10天。结果　有效率 (CR +PR)治疗组(5 7 6 % )高于对照组 (32 1% ,P <0 0 5 ) ;治疗组消化道反应及肾毒性小 ,生活质量改善明显 (P <0 0 5 )。结论　持续静滴顺铂与口服VP - 16胶囊为晚期NSCLC有效。Objective To study the efficacy of continuous infusion of cisplatin and oral etoposide in the treatment of non small cell lung cancer (NSCLC).Methods 61 cases with NSCLC(stage Ⅲ Ⅳ)were randomized into treated group(TG,33 cases)and control group(CG,28 cases).CG was treated with conventional EP regimen.TG was treated with cisplatin (20mg/m 2 daily for 4 days by i.v. continuous infusion)and etoposide capsules(50mg orally,twice daily for 10 days). Results The response rate (CR+PR) of TG(57 6%) was significantly higher than that of CG(32 1%, P <0 05).The incidence of nausea and emesis in TG(15 1%)was significantly lower than that in CG(46 4%, P <0 01).Kidney disfunction occurred less in TG. The quality of life in TG was improved better than that in CG( P <0 05). Conclusion The efficacy of continuous infusion of cisplatin and oral etoposide in the treatment of advanced NSCLC was better than that of conventional EP regimen.There were less side effects in the regimen.It was on effective,safe treatment for advanced NSCLC.

关 键 词：非小细胞肺癌 联合化疗 依托泊甙胶囊 

分 类 号：R734.205[医药卫生—肿瘤]