芦荟多糖影响肿瘤血管生成作用的初步研究  

Preliminary study on aloe polysaccharide affecting tumor angiogenesis

作　　者：卢碧玉[1] 蔡小连 

机构地区：[1]佛山科学技术学院,广东佛山528000 [2]佛山市普达美生物医药科技有限公司,广东佛山528000

出　　处：《现代医药卫生》2012年第21期3201-3201,3203,共2页Journal of Modern Medicine & Health

基　　金：广东省中医药管理局科研基金资助项目(402020)

摘　　要：目的研究芦荟多糖(AP)抑制肿瘤新生血管生成的作用。方法以细胞生长抑制率和IC50为考察指标,通过MTT法,测定AP对人脐静脉内皮细胞(ECV304)生长的抑制作用,并观察量效和时效之间的作用关系。结果各实验组表现肿瘤生长明显受到抑制,AP对ECV304细胞生长的抑制作用呈浓度和时间的依赖性。在24、48、72 h时间段测得的IC50分别为1.1120、0.3260、0.0795μg/mL。结论 AP具有明显的抗肿瘤新生血管生成作用,并呈浓度和时间上的依赖性。Objective To observe the anti-tumor angiogenesis effect of aloe polysaccharide（AP）.Methods With the inhibitory rate of cell growth and IC50 as the investigating indexes,the inhibitory action of AP on ECV304 cells was detected by MTT method,its concentration-effect and time-effect relationships were analyzed and their IC50 was also calculated.Results The various experimental groups showed that the growth ECV304 cells were significantly inhibited and the inhibitory effect of AP on ECV304 cells revealed the concentration and time dependence.IC50 detected at 24,48,72 h were 1.112,0.326 and 0.0795 μg/mL respectively.Conclusion AP has obvious anti-tumor angiogenesis effect with concentration and time dependence.

关 键 词：多糖类 芦荟 化学 肿瘤 药物疗法 肿瘤 中药疗法 肿瘤 血液供给 新生血管化 病理性 研究 芦荟多糖 

分 类 号：R73-361[医药卫生—肿瘤]