情感性精神障碍事件相关电位变异与自杀行为史的相关性  

Event-related potentials and suicide behavior in patients with affective disorder

作　　者：王继军[1] 陈兴时[1] 楼翡樱[1] 梁建华[1] 张明岛[1] 

机构地区：[1]上海市精神卫生中心,200030

出　　处：《中华医学杂志》2000年第4期275-277,共3页National Medical Journal of China

基　　金：上海市卫生局青年课题基金

摘　　要：目的　探讨情感性精神障碍患者事件相关电位变异的临床意义。方法　收集 39例抑郁相和 2 2例躁狂相患者 ,以 33例正常人为对照组 ,记录其事件相关电位P30 0和CNV (contingentnegativevariations)。结果　 (1)与正常对照组相比 ,抑郁相和躁狂相组患者均出现P30 0中P3b潜伏期延迟和P3 波幅低下 ,CNV中命令后伴随负变化 (PINV)出现率高、CNV波幅下降和反应时间 (RT)延长等 ;(2 )两组患者的P30 0和CNV改变主要与患者有无自杀行为史有关。结论　P30 0和CNV临床应用价值得到初步证实 ,与自杀行为相关的生物学指标研究中需进一步重视。Objective To investigate P300 and contingent negative variations (CNV) of patients with affective disorder and its clinical significance. Methods 39 depressives, 22 maniacs and 33 normal controls were included in this study. Both P300 and CNV were recorded in every subject, using a nicolet spirit instrument. Results Both depression and mania groups presented prolonged P300 P3b latency and decreased P300 P3 and CNV amplitudes compared with normal controls. Decreased P300 & CNV amplitudes were further related to the history of suicide behavior in the two patient groups. Conclusion The clinical significance of event related potentials was confirmed in this study, while the biological correlates of suicide behavior need further and intensive study.

关 键 词：情感性精神障碍 事件相关电位 自杀 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R395.9[医药卫生—临床医学]