不同厂家的头孢羟氨苄胶囊溶出度的比较  

Dissolution Comparison of Cefadroxil Capsules from Different Manufacturers

作　　者：钱桂英[1] 屈蓉[1] 陈佳[1] 

机构地区：[1]泰州市食品药品检验所,江苏泰州225300

出　　处：《中国药师》2012年第10期1425-1428,共4页China Pharmacist

摘　　要：目的:对9厂家的头孢羟氨苄胶囊的体外溶出行为进行比较。方法:高效液相色谱法测定9厂家头孢羟氨苄胶囊在不同介质中的溶出度,利用f2因子法比较溶出曲线。结果:9厂家的头孢羟氨苄胶囊溶出曲线与日本橙皮书溶出曲线相比,有两厂家与标准曲线相似。结论:国内部分厂家的头孢羟氨苄胶囊的溶出过程批间有一定差异。Objective： To compare the dissolution in vitro of cefadroxil capsules from nine different manufacturers.Method： The content and the cumulative dissolution of cefadroxil capsules from the manufacturers were respectively determined by HPLC.The dissolution curves were compared by f2 factor.Result： The dissolution curves of the capsules from two manufacturers were similar to the standard curve from Japanese Orange book.Conclusion： There are significant differences in the dissolution characteristics of the cefadroxil capsules from different pharmaceutical factories in our country.

关 键 词：头孢羟氨苄胶囊 溶出度 溶出曲线 F2因子 

分 类 号：R927.11[医药卫生—药学]