保肝消脂冲剂对高糖高脂饲料诱导的大鼠非酒精性脂肪肝的治疗作用  

Effect of Baoganxiaozhi Granule on non-alcoholic fatty liver induced by high glucose and fatty diet in rats

作　　者：王静滨[1] 谢晶日[1] 陆振华[1] 

机构地区：[1]黑龙江中医药大学附属第一医院肝脾胃病科,黑龙江哈尔滨150040

出　　处：《中国中西医结合消化杂志》2012年第11期493-497,共5页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

摘　　要：[目的]观察保肝消脂冲剂对高糖高脂饲料诱导的大鼠非酒精性脂肪肝(NAFL)的治疗作用。[方法]雄性Wistar大鼠80只中20只作为正常对照组;其余60只用高糖高脂肪饲料喂养30d建立NAFL模型,造模成功后分组并给药治疗,连续给药8周。检测各组大鼠血清和肝脏中生化指标,做肝脏组织病理学检查。[结果]NAFL大鼠经保肝消脂冲剂治疗后,血清中三酰甘油(TG)含量和谷丙转氨酶活性显著降低(P<0.01);肝组织中TG、总胆固醇、丙二醛、游离脂肪酸含量减少,超氧化物歧化酶活力增加(P<0.01);肝细胞脂肪肝程度明显减轻,肝细胞坏死程度减轻。[结论]保肝消脂冲剂能降低NAFL大鼠血液和肝脏中TG含量,对NAFL有治疗作用,其作用机制可能与其抗氧化作用,减轻脂质过氧化引起的肝脏损伤,降低肝脏脂肪沉积有关。[Objective]To observe the therapeutic effect of Baoganxiaozhi Granule（BXG） on rats with non-alcoholic fatty liver （NAFL） induced by high glucose and fatty diet. [Methods]Rat model of NAFL was constructed by administration with high glucose and fatty diet for 30 days. After the models were established, the rats were then fed with normal diet, and they were randomly divided into BXG group, Ganle Tablet group and NS group respectively. 8weeks later, the biochemical indicators in blood serum and hepatic tissue were detected. [Results] The content of TG and the activity of ALT in blood serum declined after BXG treatment（P〈0.05）, so did the content of TG,TC and MDA in hepatic tissue. The activity of SOD in hepatic tissue increased in rats with NAFL after being treated with BXG for four weeks（P〈0.05）. The degree of hepatocyte fatty degeneration and hepatocyte necrosis was obviously improved. [Conclusion] BXG can reduce the content of TG in blood serum and hepatic tissue in rats with NAFL induced by high glucose and high-fat diet, and is effective for treating non-alcoholic fatty liver. The mechanism of action may be associated with BXG＇s antioxidation,lessened liver damage induced by lipid peroxidation and reduced fatty deposition in the liver.

关 键 词：脂肪肝 非酒精性 实验研究 保肝消脂冲剂 

分 类 号：R575.5[医药卫生—消化系统]