瘤内微血管密度与胃癌临床病理特征相关性研究  

The Study of the Relationship between Intratumor Microvessel Density and the Clinicopathological Features of Gastric Carcinoma

作　　者：王爱东[1] 吕光成[1] 

机构地区：[1]苏州医学院附属一院普外科,苏州215006

出　　处：《苏州医学院学报》2000年第6期543-544,547,共3页Acta Academiae Medicinae Suzhou

摘　　要：目的　探讨肿瘤内血管生成在胃癌生长、侵袭、转移中的作用。方法　采用免疫组织化学SP法 ,用抗血管内皮CD34单克隆抗体对 40例胃癌及 10份正常胃组织标本进行标记分析。结果　肿瘤微血管密度 (MVD)较正常胃组织显著增高 (P <0 .0 1) ;淋巴结转移组MVD显著高于无淋巴结转移组 (P <0 .0 1) ;肿瘤肝脏转移组MVD较无肝转移组增高 (P <0 .0 5 )。结论　瘤内血管密度与胃癌的侵袭、转移密切相关 ,血管生成可能促进胃癌的发展并影响其预后。Objective To evaluate the role of angiogenesis in growth、invasion and metastasis of gastric carcinoma.Methods The microvessel density(MVD)was determined by immunohistochemical SP method using a monoclonal antibody to CD 34 in samples of 40 gastric carcinoma and 10 normal gastric tissue.Results MVD was significantly higher in carcinoma than that in normal gastric samples( P <0.01)and higher in the groups with lymphnode involvement or liver metastases than that without lymphnode involvement or liver metastases( P <0.01 and P <0.05 Respectively).Conclusions Intratumor MVD is strongly related to the invasion and metastasis of gastric carcinoma. Angiogenesis might promote the progression of gastric carcinoma and affect the prognosis of the patients.

关 键 词：胃肿瘤 瘤内微血管密度 肿瘤侵袭 肿瘤转移 

分 类 号：R735.202[医药卫生—肿瘤] R73－37[医药卫生—临床医学]