膀胱肿瘤患者中表皮生长因子水平临床意义  

Urinary epidermal growth factor and its correlation with bladder cancer

作　　者：汪清[1] 赵伟 盛新福[1] 赵金平 

机构地区：[1]新疆医科大学第一附属医院泌尿外科,新疆乌鲁木齐830054 [2]新疆昌吉兵团农六师医院外科,831100

出　　处：《新疆医科大学学报》2000年第2期131-133,共3页Journal of Xinjiang Medical University

摘　　要：目的 :对 12 7例不同年龄结构的正常人群和 2 8例膀胱肿瘤患者尿中 EGF水平进行测定。 方法 :采用I1 2 5 - EGF的放射免疫法测定 EGF水平。 结果 :小儿组 (15例 ) EGF浓度 (31.19± 7.46 ) μg/L;正常人群组 (92例 )EGF浓度 (16 .5 2± 1.6 9)μg/L ;膀胱肿瘤组 (2 8例 ) EGF浓度 (14.6 4± 1.86 )μg/L ;前列腺增生组 (BPH,2 0例 ) EGF浓度 (7.91± 1.11)μg/L。膀胱肿瘤组与正常人群组比较有统计学差异 (P <0 .0 5 ) ;年龄的变化也有统计学差异 (P<0 .0 5 )。 结论 :EGF与年龄有相关性 ;EGF是一个较可靠。Objeetive: Epidermal growth factor (EGF) is a principal growth factor mediating tumor angiogenesis. The EGF within bladder tumor is associated with a poor prognosis. We quantified urinary EGF and determined its potential as a prognostic marker in bladder cancer. Methods: EGF was measured by I 125 EGF assay in the urine of 127 patients,including 28 cases of bladder cancer,The source of urinary EGF was studied through its quantification in bladder tumors and normal bladders. Results: Urinary EGF was lower in patients of bladder tumor than in those with benign urological conditions (P<0.005) or children group. Conclusion: Our study demonstrates that EGF is lower in the urine of patients with bladder cancer and it correlates with tumor. Its quantification may provide a valuable noninvasive marker for the early detection of bladder tumor recurrence as well as a therapy target.

关 键 词：表皮生长因子 尿液 膀胱肿瘤 诊断 

分 类 号：R737.140.4[医药卫生—肿瘤] R730.43[医药卫生—临床医学]